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UNLABELLED We evaluated the safety, pharmacokinetic profile, pharmacodynamic effects, and antitumor activity of abemaciclib, an orally bioavailable inhibitor of cyclin-dependent kinases (CDK) 4 and 6, in a multicenter study including phase I dose escalation followed by tumor-specific cohorts for breast cancer, non-small cell lung cancer (NSCLC),(More)
OBJECTIVE Out-of-hospital cardiac arrest is one of the leading causes of death in Mexico, but many survival and prognostic factors are unknown. The aim of this study was to assess out-of-hospital cardiac arrest in a Mexican city. METHODS This was a prospective, cohort study that evaluated the records of the major ambulance services in the city of(More)
The objectives of this paper are to define and classify different types of errors and artefacts that can appear in the process of developing an agent-based model, and to propose activities aimed at avoiding them during the model construction and testing phases. To do this in a structured way, we review the main concepts of the process of developing such a(More)
In June 2009, the World Health Organization declared a novel influenza A, S-OIV (H1N1), pandemic. We observed 44 consecutive patients during the "first wave" of the pandemic. 70.5% of them showed co-morbidities (hypertension, obesity, chronic respiratory diseases, chronic renal disease, diabetes, pregnancy). Serious cases were admitted to the intensive care(More)
In the current global market, traditional hierarchical approaches for manufacturing scheduling and control don't produce the desired results. It occurs especially in Job-Shop manufacturing configurations. In order to overcome the limitations that hierarchical and centralized architectures show in new manufacturing systems, many decentralized schemes have(More)
In this work we use the paradigm of multiagent systems to solve the Job Shop problem. Job Shop problem is a particular problem of scheduling in which we try to find an schedule that optimize a objective and is subject to certain constraints. We propose a combinatorial auction mechanism to coordinate agents. The " items " to be sold are the time slots that(More)