Ricardo Viegas Cremonese

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BACKGROUND Long-term administration of carbon tetrachloride is an accepted experimental model to produce hepatic fibrosis. Oxidative stress has been postulated as a major molecular mechanism involved in carbon tetrachloride hepatotoxicity, where the reactive oxygen species play an important role in the pathogenesis of liver fibrosis. AIMS This study was(More)
OBJECTIVE To determine whether the predictive accuracy of clinical judgment alone can be improved by supplementing it with an objective weaning protocol as a decision support tool. METHODS This was a multicenter prospective cohort study carried out at three medical/surgical ICUs. The study involved all consecutive difficult-to-wean ICU patients (failure(More)
OBJECTIVE To evaluate the predictive value of central venous saturation to detect extubation failure in difficult-to-wean patients. DESIGN Cohort, multicentric, clinical study. SETTING Three medical-surgical intensive care units. PATIENTS All difficult-to-wean patients (defined as failure to tolerate the first 2-hr T-tube trial), mechanically(More)
BACKGROUND Cancer patients may require intensive care support for postoperative care, complications associated with underlying malignancy, or toxicities related to cancer therapy. The higher mortality rates found in this population than in the population of ICU patients without cancer may be attributable to confounding due to a higher prevalence of multiple(More)
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