Ricardo Simão Vieira-Pires

Learn More
In bacteria, archaea, fungi and plants the Trk, Ktr and HKT ion transporters are key components of osmotic regulation, pH homeostasis and resistance to drought and high salinity. These ion transporters are functionally diverse: they can function as Na(+) or K(+) channels and possibly as cation/K(+) symporters. They are closely related to potassium channels(More)
KCNH channels are voltage-gated potassium channels with important physiological functions. In these channels, a C-terminal cytoplasmic region, known as the cyclic nucleotide binding homology (CNB-homology) domain displays strong sequence similarity to cyclic nucleotide binding (CNB) domains. However, the isolated domain does not bind cyclic nucleotides.(More)
Structures of three potassium channels of the six-trans-membrane (TM) helix type, a ligand-gated channel, and two voltage-gated channels were solved recently by x-ray crystallography (Long et al., 2005a,b, 2007; Clayton et al., 2008). In all three channel structures, the fourth TM segment (the voltage sensor in the voltage-gated channels) of each subunit(More)
KtrAB belongs to the Trk/Ktr/HKT superfamily of monovalent cation (K+ and Na+) transport proteins that closely resemble K+ channels. These proteins underlie a plethora of cellular functions that are crucial for environmental adaptation in plants, fungi, archaea, and bacteria. The activation mechanism of the Trk/Ktr/HKT proteins remains unknown. It has been(More)
  • 1