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UNLABELLED We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01(More)
Many issues still remain to be addressed in order to achieve acceptable security in Wireless Sensor Networks (WSNs). This necessity, together with the adoption of IPv6 on WSNs being defined at the 610wpan lvorking group of the IETF, motivates our investigation on the feasibility of the application of IPSec on sensor nodes. IPSec is already part of IPv6,(More)
The views and conclusions contained in this document are those of the author and should not be interpreted as representing the official policies, either expressed or implied, of any sponsoring institution, the U.S. government or any other entity. Abstract Much of our understanding of Nature comes from theories about unobservable entities. Identifying which(More)
The GINSENG project develops performance-controlled wireless sensor networks that can be used for time-critical applications in hostile environments such as industrial plant automation and control. GINSENG aims at integrating wireless sensor networks with existing enterprise resource management solutions using a middleware. A cornerstone is the evaluation(More)
The fast growing of mobile Internet users with the ability of using a wide diversity of access technologies such as Wi-Fi, WiMAX and UMTS/LTE, and the increasing proliferation of mobile devices with heterogeneous network interfaces, require versatile mobility mechanisms providing seamless roaming across those access technologies. Mobility agents such as(More)
Machine learning has matured to the point to where it is now being considered to automate decisions in loan lending, employee hiring, and predictive policing. In many of these scenarios however, previous decisions have been made that are unfairly biased against certain subpopulations (e.g., those of a particular race, gender, or sexual orientation). Because(More)
Protein Kinase (casein kinase 2, CK2) is a serine-threonine kinase that is frequently dysregulated in many human tumors. Therefore we hypothesized that peptides capable of binding to the CK2 acidic domain may exhibit potential anticancer properties. By screening a random cyclic peptide phage display library, we have identified a novel peptide, P15, that(More)
To characterize the effect of the envelope fragment fusion site in the P64k protein from Neisseria meningitidis several chimeric constructs were obtained. One variant consisted in the insertion of the E fragment from each Dengue serotype within the lipoil binding domain of the P64k, whereas the other was based on the fusion of the envelope fragment at the(More)