Ricardo Saraiva de Camargo

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In telecommunication and transportation systems, the uncapacitated multiple allocation hub location problem (UMAHLP) arises when we must flow commodities or information between several origin–destination pairs. Instead of establishing a direct node to node connection from an origin to its destination, the flows are concentrated with others at facilities(More)
Proteasome inhibitors have been described as an important target for cancer therapy due to their potential to regulate the ubiquitin-proteasome system in the degradation pathway of cellular proteins. Here, we reported the effects of a Bowman-Birk-type protease inhibitor, the Black-eyed pea Trypsin/Chymotrypsin Inhibitor (BTCI), on proteasome 20S in MCF-7(More)
Generally, Trypanosoma cruzi infection in human is persistent and tends to chronicity, suggesting that the parasite evade the immune surveillance by down regulating the intracellular antigen processing routes. Within the MHC class I pathway, the majority of antigenic peptides are generated by the proteasome. However, upon IFN-γ stimulation, the catalytic(More)