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In this paper the long-term scheduling of a real world multi-product single stage continuous process for manufacturing glass is studied. This process features long minimum run lengths, and sequence dependent changeovers of the order of days, with high transition costs. The long-term scheduling involves extended time horizons that lead to large scale mixed(More)
In this paper, we identify some of the computational advances that have been contributing to the efficient solution of mixed-integer linear programming (MILP) problems. Recent features added to MILP solvers at the algorithmic level and at the hardware level have been contributing to the increasingly efficient solution of more difficult and larger problems.(More)
This paper addresses the solution of a nonlinear boolean quadratic programming problem using three different approaches. The first uses a classic linearization technique to transform the original problem into a Mixed Integer Linear Programming (MILP) problem for which multiple formulations are studied. The second uses the capabilities of current MILP(More)
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease that manifests in hypoxemia, inactivity, and poor prognosis. This study aimed to assess the prognostic role of physical activity (PA) and exertional desaturation (ED) with mortality in IPF. At baseline, 34 IPF patients (68 (50-81) years) were interviewed using the International Physical Activity(More)
Flexibility analysis and robust optimization are two approaches to solving optimization problems under uncertainty that share some fundamental concepts, such as the use of polyhedral uncertainty sets and the worst-case approach to guarantee feasibility. The connection between these two approaches has not been sufficiently acknowledged and examined in the(More)
—This paper addresses the global optimization of the short term scheduling for hydroelectric power generation. A Mixed Integer Nonlinear Programming (MINLP) model is proposed for a cascade of hydro plants, each one with multiple turbines, characterized by a detailed representation of the net head of water and a nonlinear hydropower generation function. In(More)
OBJECTIVE To investigate the blood pressure (BP) responses to cardiovascular stress test after a combined exercise circuit session at moderate intensity. METHOD Twenty individuals (10 male/10 fem; 33.4± 6.9 years; 70.2± 15.8 kg; 170.4± 11.5 cm; 22.3± 6.8% body fat) were randomized in a different days to control session with no exercise or exercise session(More)
  • Cláudia C. Lunardi, Ricardo M. Lima, Rinaldo W. Pereira, Tailce K. M. Leite, Ana B. M. Siqueira, Ricardo J. Oliveira
  • 2013
A previous genome-wide association study suggested that polymorphisms in the thyrotrophin-releasing hormone receptor (TRHR) gene contribute to fat-free mass (FFM) variation. The aim of the present study was to examine the association between polymorphisms in the TRHR gene with FFM and muscle strength in older women. Volunteers (n = 241; age = 66.65 ± 5.5(More)
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