Ricardo F. L. Moreno

Learn More
The effects of benzyl (BITC) and phenethyl isothiocyanate (PEITC) on the activity of a P450 2E1 mutant where the conserved threonine at position 303 was replaced with an alanine residue (P450 2E1 T303A) were examined. PEITC inactivated the mutant enzyme with a K(I) of 1.6 microM. PEITC also inactivated the wild-type P450 2E1 as efficiently with a K(I) of(More)
The cytochrome P450 enzymes constitute a family of phase I enzymes that play a prominent role in the metabolism of a great variety of endogenous and xenobiotic compounds. In this study, the kinetics for the inactivation of cytochrome P450 2E1 by benzyl isothiocyanate (BITC) were elucidated. BITC is a naturally occurring compound found in cruciferous(More)
A new approach for small transconductance (Gm) OTA designs, suitable for relatively low frequency filtering applications in the range of few kHz, is proposed. Small Gm values are achieved by a current cancellation technique, and are adjustable by bulk driving the MOS transistors of the input differential amplifier. The OTA design procedure takes into(More)
  • 1