Ricardo Dias

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An approach is described to the design of beta-hairpin peptidomimetic ligands for bovine immunodeficiency virus (BIV) Tat protein, which inhibit binding to its transactivator response element (TAR) RNA. A library of peptidomimetics was derived by grafting onto a hairpin-inducing d-Pro-l-Pro template sequences related to the RNA recognition element in Tat.(More)
Antibiotics with new mechanisms of action are urgently required to combat the growing health threat posed by resistant pathogenic microorganisms. We synthesized a family of peptidomimetic antibiotics based on the antimicrobial peptide protegrin I. Several rounds of optimization gave a lead compound that was active in the nanomolar range against(More)
Inhibitors of the interaction between the p53 tumor-suppressor protein and its natural human inhibitor HDM2 are attractive as potential anticancer agents. In earlier work we explored designing beta-hairpin peptidomimetics of the alpha-helical epitope on p53 that would bind tightly to the p53-binding site on HDM2. The beta-hairpin is used as a scaffold to(More)
Phage display is a powerful method for selecting peptides with novel binding functions. Synthetic peptidomimetic chemistry is a powerful tool for creating structural diversity in ligands as a means to establish structure-activity relationships. Here we illustrate a method of bridging these two methodologies, by starting with a disulfide bridged phage(More)
The Tat protein of immunodeficiency viruses is the main activator of viral gene expression. By binding specifically to its cognate site, the transactivator response element (TAR), Tat mediates a strong induction of the production of all viral transcripts. In seeking a new chemical solution to inhibiting viral protein-RNA interactions, we recently identified(More)
The search for new antiviral drugs that repress HIV viral replication by blocking transactivation of viral RNA transcription has long been advocated as an approach to novel antiviral therapy. However, research in this area has so far failed to yield attractive lead compounds because of the insufficient development of RNA-based medicinal chemistry. One(More)
Over the past years, music listening histories have become easily accessible due to the expansion of online lifelogging services. These histories represent the sequence of songs listen by users over time. Although this data contains intrinsic users' tastes and listening behaviors, it has been mainly used to personalize recommendations. Tools to help users(More)
In this paper we present MuVis, an interactive visualization and exploration tool for large music collections, based on music content and metadata. We combined a user-centered design with three main components: information visualization techniques (based on semantic ordered treemaps), music information retrieval mechanisms (for semantic and content-based(More)
Music recommendation systems based on Collaborative Filtering methods have been extensively developed over the last years. Typically, they work by analyzing the past user-song relationships, and provide informed guesses based on the overall information collected from other users. Although the music listening behavior is a repetitive and time-dependent(More)