Ricardo Carvalho Amorim

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Research data management is acknowledged as an important concern for institutions and several platforms to support data deposits have emerged. In this paper we start by overviewing the current practices in the data management workflow and identifying the stakeholders in this process. We then compare four recently proposed data repository platforms—DSpace,(More)
The value of research data is recognized, and so is the importance of the associated metadata to contextualize, describe and ultimately render them understandable in the long term. Laboratory notebooks are an excellent source of domain-specific metadata, but this paperbased approach can pose risks of data loss, while limiting the possibilities of(More)
The studies of potentiation of 5-fluorouracil (5-FU), a traditional drug used in the treatment of several cancers, including colorectal (CRC), were carried out with zeolites Faujasite in the sodium form, with different particle sizes (NaY, 700nm and nanoNaY, 150nm) and Linde type L in the potassium form (LTL) with a particle size of 80nm. 5-FU was loaded(More)
Research data management is rapidly becoming a regular concern for researchers, and institutions need to provide them with platforms to support data organization and preparation for publication. Some institutions have adopted institutional repositories as the basis for data deposit, whereas others are experimenting with richer environments for data(More)
Cancer cells rely mostly on glycolysis to meet their energetic demands, producing large amounts of lactate that are extruded to the tumour microenvironment by monocarboxylate transporters (MCTs). The role of MCTs in the survival of colorectal cancer (CRC) cells is scarce and poorly understood. In this study, we aimed to better understand this issue and(More)
Oxidative stress and mitochondrial dysfunction have been associated with metabolic and age-related diseases. Thus, the prevention of mitochondrial oxidative damage is nowadays a recognized pharmacological strategy to delay disease progression. Epidemiological studies suggested an association between the consumption of polyphenol-rich diet and the prevention(More)
Background Tumour cells relies mostly on glycolysis to meet their energetic demands thus leading to an overload of lactic acid, which must be exported to the extracellular milieu, through the monocarboxylate transporters (MCTs). Due to their upregulation in cancer, MCTs are currently seen as promising therapeutic targets in cancer. Colorectal carcinoma(More)
Over the last decades, paraquat (1,1'-dimethyl-4,4'-bipyridilium dichloride; PQ) has been involved in numerous fatalities especially attributed to suicide attempts. Previously, it was shown that salicylates, namely sodium salicylate (NaSAL) and lysine acetylsalicylate (LAS) may form complexes with PQ, which may contribute to prevent its toxicity. The direct(More)