Ricardo André Amorim Leite

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Schistosoma mansoni is the primary causative agent of schistosomiasis, which affects 200 million individuals in 74 countries. We generated 163,000 expressed-sequence tags (ESTs) from normalized cDNA libraries from six selected developmental stages of the parasite, resulting in 31,000 assembled sequences and 92% sampling of an estimated 14,000 gene(More)
TO THE EDITOR Individuals with xeroderma pigmentosum syndrome (XP) present an extremely high sensitivity to sunlight, with increased incidence of skin cancer (especially in sun-exposed areas), when compared to the normal population. Some XP patients can also display developmental complications and early aging features. A genetic defect in the nucleotide(More)
P53 activation is one of the main signals after DNA damage, controlling cell cycle arrest, DNA repair and apoptosis. We have previously shown that confluent nucleotide excision repair (NER)-deficient cells are more resistant to apoptosis induced by ultraviolet irradiation (UV). Here, we further investigated the effect of cell confluence on UV-induced(More)
Recombinant adenoviral vectors provide efficient means for gene transduction in mammalian cells in vitro and in vivo. We are currently using these vectors to transduce DNA repair genes into repair deficient cells, derived from xeroderma pigmentosum (XP) patients. XP is an autosomal syndrome characterized by a high frequency of skin tumors, especially in(More)
The effect of sublethal whole body irradiation (800 rads) on the level and biological activities of antibodies in mice chronically infected with the CL strain of Trypanosoma cruzi was studied. Irradiated mice died, although a high parasitemia did not always preceded death. Before and after irradiation, a constant level of antibodies was detected by(More)
The progress of epilepsies diagnosis has been great, but, amongst the diagnostic detailing that demand research, one of the most important is the essential lateralization and localization of epileptogenic zone, considered as the cerebral cortex region, that removed, will result in a free state of seizures. The present study aims to analyze the possible uses(More)
OBJECTIVE To analyze the agreement rate of proton magnetic spectroscopy with magnetic resonance image (MRI) and surface electroencephalography (EEG) in extratemporal neocortical epilepsies. METHODS A cross-sectional study, type series of cases included 33 patients, age range 13-59 years old, of both gender, presenting structural alteration identified by(More)
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