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Prior studies demonstrate an association between specific beta-adrenergic receptor (β-AR) polymorphisms and clinical outcomes in patients with chronic heart failure and following acute coronary syndromes. The underlying mechanism may be due to differences in left ventricular remodeling. This study was undertaken to explore the relationship between LV(More)
OBJECTIVES The purpose of this study was to determine if an incomplete response to or inadequate antiplatelet effect of aspirin, or both, contribute to saphenous vein graft (SVG) occlusion after coronary artery bypass graft (CABG) surgery. BACKGROUND Thrombosis is the predominant cause of early SVG occlusion. Aspirin, which inhibits cyclooxygenase-1(More)
PURPOSE Whether either natural emmetropization or compensation for imposed spectacle lenses requires the visual system to distinguish myopic from hyperopic blur is controversial. Some have argued that the visual system need only respond to the magnitude of the blur. This study was undertaken to test whether adding large amounts of astigmatic image blur(More)
AIM The aim of the present study was to investigate the relative importance of a wide array of patient demographic, procedural, anatomic and perioperative variables as potential risk factors for early saphenous vein graft (SVG) thrombosis after coronary artery bypass graft (CABG) surgery. METHODS The patency of 611 SVGs in 291 patients operated on at four(More)
INTRODUCTION Patients with chronic kidney disease (CKD) have increased morbidity following invasive procedures. We hypothesized that patients with CKD have higher complication rates following device implantation than patients with normal renal function. METHODS We reviewed the medical records of patients undergoing ICD or pacemaker implantation from(More)
Heart failure affects nearly 6 million people in the United States alone,1 and the prevalence has reached alarming proportions. It is estimated that approximately 2%of Americans have heart failure, and 35%of cardiovasculardeathsaredirectly relatedtoheart failure.1 Thecosts for treatingpatientswithheart failurenowapproach $32 billion annually.2 Successful(More)
Previous studies have demonstrated that β-adrenergic receptor polymorphisms affect outcomes in patients with heart failure or after an acute coronary syndrome. Whether β-adrenergic polymorphisms influence catecholamine responses in patients with cardiovascular disease is not known. Cardiovascular responses to the β1-receptor agonist dobutamine and the(More)