Rhodri Anderson

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The effects of benoxaprofen on spontaneous and concanavalin A-induced suppressor activity in human mononuclear leucocytes (MNL) were assessedin vitro. The drug was used at a fixed concentration of 10−4 M (30 μg/ml) in these studies. Benoxaprofen-treated MNL suppressed the responsiveness of untreated autologous MNL to the mitogen phytohaemagglutinin and(More)
Hypochlorous acid (HOCl) at concentrations of 6.25 μM and greater caused statistically significant, dose-related inhibition of mitogen-activated proliferation of human mononuclear leucocytes (MNL). The anti-proliferative effects of HOCl, which were evident using both undepleted and adherent-cell depleten MNL, could not be attributed to decreased mitogen(More)
Both H2O2 (IC50=70 μM) and HOCl (IC50=8.5 μM) inhibited mitogen-induced MNL proliferation in a dose-dependent manner. This was found to be due to a depletion of intracellular ATP by at least two distinct mechanisms. HOCl and high concentrations (>100 μM) of H2O2 inhibit ATP generation via sulfhydryl group oxidation on the active site of the(More)
Infection with the Daniel strain of Theiler's murine encephalomyelitis (TMEV-DA) virus induces persistent demyelinating lesions in mice and serves as a model for multiple sclerosis. During the acute phase of the disease, however, viral infection leads to cell death in vivo. Viral-induced death may result directly from viral infection of neural cells, or(More)
Benoxaprofen inhibited the random motility and migration to the leucoattractants endotoxin-activated serum (EAS) and f-met-leu-phe of human polymorphonuclear leucocytes (PMNL)in vitro. Inhibition of random and leucoattractant-induced migration was observed at drug concentrations of >1×110−6 M and 1×10−5 M respectively. Benoxaprofenper se was not leucotactic(More)
The pathways regulating integrin-mediated adhesion during neutrophil migration are incompletely defined. Using a flow-based model in which human neutrophils rolling on P-selectin were activated to migrate by the chemoattractant peptide fMLP, we investigated the role of phospholipase D (PLD). fMLP-stimulated PLD generation of phosphatidate (PtdOH); while(More)
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