Learn More
The effects of 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS 21680) on blood pressure, total peripheral resistance, cardiac index, heart rate and arterial conductance in different vascular beds in the presence and absence of hexamethonium (ganglionic blocker) and phenylephrine (alpha 1-adrenoceptor agonist) were investigated in(More)
Adenosine is widely distributed in mammals. One of the primary roles of adenosine within the cardiovascular system is to directly control the functions of both cardiac and vascular tissues. Recently, there has been considerable interest in the subclassification of adenosine receptors. Characterization of a heterogeneous population of receptors for adenosine(More)
  • R Tabrizchi
  • Current opinion in investigational drugs
  • 2000
Mitsubishi-Tokyo (formerly Mitsubishi Chemical) is developing edaravone (norphenazone), a free radical scavenger, for the potential treatment of cardiovascular disease, cerebrovascular ischemia and cerebral edema. By February 2000, edaravone had been filed in Japan for the treatment of acute brain infarction, and was in phase III trials for subarachnoid(More)
  • R. Tabrizchi
  • Naunyn-Schmiedeberg's Archives of Pharmacology
  • 1997
The effects of adenosine and adenosine analogues, 2-[p-(2-[carboxyethyl) phenethylamino]-5’-N-ethylcarboxamidoadenosine (CGS 21680) and N6-2-(4-aminophenyl)-ethyladenosine (APNEA), on mean arterial pressure, cardiac output, mean circulatory filling pressure, arterial resistance, venous resistance and heart rate in untreated or treated (with(More)
The effect of isoprenaline on tone, cyclic adenosine 3′:5′ monophosphate (cAMP), and smooth muscle membrane potential (E m ) were assessed in rat isolated pulmonary arteries. Nω-nitro-L-arginine methyl ester (10.0 μM) or removal of endothelium partially inhibited relaxant responses to isoprenaline, but glibenclamide (10.0 μM) and indomethacin (10.0 μM) did(More)
The effects of N omega-nitro-L-arginine methyl ester (L-NAME) were examined on pressor responses elicited by sympathetic nerve stimulation (SNS) in the pithed spontaneously hypertensive (SH) and Wistar-Kyoto (WKY) rats. Frequency-response curves (1-20 Hz) were carried out by using the pithing rod to stimulate the sympathetic chain. SNS produced an increase(More)
The influence of increases in osmolarity by addition of sucrose were investigated on relaxation and changes in adenosine 3':5'-cyclic monophosphate (cyclic AMP) and guanosine 3':5'-cyclic monophosphate (cyclic GMP) levels in isolated rat aortic rings. Isoprenaline-mediated relaxations were attenuated in hypertonic (341+/-0.4 mOsmol) (mean+/-S.E.M.)(More)
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. The activation of PPAR-gamma, an isotype of PPARs, can either increase or decrease the transcription of target genes. The genes controlled by this form of PPAR have been shown to encode proteins or peptides(More)
It is the function of the vascular system, through a complex network of arteries, capillaries and veins, to maintain cellular homeostasis. As research scientists it is necessary to understand not only some of the basic properties of the blood vessel itself but also how these vessels differ in cellular and physiological function. This review provides an(More)
1.--We have examined the relationship between the resting membrane potential (E(m)) and the concentration of the external ions, K(+), Cl(-) and Ca(2+), as well as the effects of K(+) on active force generation in human saphenous veins. 2.--As measured with sharp glass microelectrodes, the E(m) of vascular muscle cells was -76.0 +/- 7.0 mV (mean +/- SD; n =(More)