Reza Tabrizchi

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Pharmacological differences between neurogenic sympathetic responses in rat and pig isolated pulmonary arteries were examined in strip preparations. Electrical field stimulation in the range of 0.6 to 40 Hz resulted in frequency-dependent contractions in terms of amplitude and rate of rise. Responses in the rat declined sharply from pulmonary trunk to main(More)
OBJECTIVE An increase in transmural pressure reportedly depolarizes myocytes in various arterial blood vessels. We have examined the relationship between transmural pressure and membrane potential (E(m)) in human saphenous veins with a view to determine whether contractile force generation, hence spasmogenesis in vein grafts, involves a similar process of(More)
Risk of cardiovascular events and cyclooxygenase-2 inhibitors Selective cyclooxygenase-2 (Cox-2) inhibitors have been at the centre of public attention since the revelation that the use of these drugs is associated with an increased risk of cardiovascular events (Tabrizchi 2005). Certainly pharmaco vigilance has an important place in the public domain and(More)
Incidence of stroke after myocardial infarction Evidence presented from a recent community-based cohort designed study by Witt and colleagues (2005) suggests that the risk of stroke substantially increases following myocardial infarction (MI). While this suggestion is not new, this particular study was longitudinal in design, spanning a period of 2 decades(More)
Guidelines for choosing drugs in chronic heart failure In a recent article, Komajda and colleagues (2005) presented data gathered from the Medical Management of Chronic Heart Failure in Europe and its Related Costs (MAHLER) survey in support of the view that adherence to guidelines in treating patients with chronic heart failure is a strong predictor of(More)