Reza Tabrizchi

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The direct and indirect effects of angiotensin II (ANGII) on mean arterial pressure (MAP) and mean circulatory filling pressure (MCFP), an index of body venous tone, were investigated in conscious rats. Dose-response curves of ANGII were constructed in control rats (Group I), rats pretreated with saralasin (competitive ANGII antagonist, Group II), with(More)
Risk of cardiovascular events and cyclooxygenase-2 inhibitors Selective cyclooxygenase-2 (Cox-2) inhibitors have been at the centre of public attention since the revelation that the use of these drugs is associated with an increased risk of cardiovascular events (Tabrizchi 2005). Certainly pharmaco vigilance has an important place in the public domain and(More)
Ecosinoids and blood vessel structure We should, perhaps, pay more attention to the influence that ecosinoids have on blood vessel behavior and structure, as substances such as nonsteroidal antiinflammatory drugs (NSAIDs) and the so called selective cyclooxygenase 2 inhibitors are extensively employed by the population at large. In this issue of Vascular(More)
Corticosteroids and endothelial dysfunction Assessment of endothelial-mediated relaxation in situ is rapidly becoming the standard gauge of individual susceptibility to future cardiovascular dysfunction (Hadi et al 2005). In this issue of Vascular Health and Risk Management, Turner and colleagues (2005), in a pilot investigation, have proposed the concept(More)
Incidence of stroke after myocardial infarction Evidence presented from a recent community-based cohort designed study by Witt and colleagues (2005) suggests that the risk of stroke substantially increases following myocardial infarction (MI). While this suggestion is not new, this particular study was longitudinal in design, spanning a period of 2 decades(More)
Welcome to the inaugural issue of Vascular Health and Risk Management. It is our hope that this journal will provide a vehicle for the timely publication of important clinical information from studies undertaken by the international scientific community in academia and other institutions (ie, public, private, and government). Here at Dove Medical Press, we(More)
OBJECTIVE An increase in transmural pressure reportedly depolarizes myocytes in various arterial blood vessels. We have examined the relationship between transmural pressure and membrane potential (E(m)) in human saphenous veins with a view to determine whether contractile force generation, hence spasmogenesis in vein grafts, involves a similar process of(More)
Metabolic syndrome: sign of things to come In a recent article in Vascular Health and Risk Management, Paoletti and colleagues (2006) pointed out that individuals with metabolic syndrome (MS) have twice the risk of dying and three times higher risk of having heart attacks or stroke compared with individuals without this syndrome. Moreover, people with MS(More)
The effects of the T-type and L-type Ca2+ channel antagonists, mibefradil and nifedipine, respectively, and those of a Cl- channel antagonist, indanyloxyacetic acid 94, on mechanical responses elicited by selective activation of alpha1-adrenoceptors using cirazoline were examined in rat isolated aortic rings. The presence of mibefradil (300 nM),(More)