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OBJECTIVE(S) Diabetes mellitus is a public health problem and one of the five leading causes of death globally. In the present study, the effect of Metformin with natural honey was investigated on glycemia in the Streptozotocin-induced diabetic rats. MATERIALS AND METHODS Thirty Wistar male rats were randomly divided into six groups including C: non(More)
Drought stress is a major factor in reduce growth, development and production of plants. Stress was applied with polyethylene glycol (PEG) 6000 and water potentials were: zero (control),-0.15 (PEG 10%),-0.49 (PEG 20%),-1.03 (PEG 30%) and-1.76 (PEG40%) MPa. The solutes accumulation of two maize (Zea mays L.) cultivars-704 and 301-were determined after(More)
Isoniazid is one of the most commonly used drugs to treat tuberculosis. Its administration is associated with a high incidence of hepatotoxicity. The aim of this study was to establish the protective effects of taurine against cytotoxicity induced by isoniazid and its suspected toxic metabolite hydrazine in isolated rat hepatocytes by measuring reactive(More)
Amodiaquine is an antimalarial drug used in the prophylaxis and treatment of this disease. However, hepatotoxicity as a life-threatening adverse effect is associated with its clinical use. We evaluated amodiaquine-induced toxicity in isolated rat hepatocytes as an in vitro model for studying drug-induced hepatotoxicity. This study attempts to investigate(More)
Methimazole is used as an antithyroid drug to control the symptoms of hyperthyroidism and maintain patients in a euthyroid state. Administration of this drug is associated with agranulocytosis and hepatotoxicity, which are the two most significant adverse effects. The present investigation was conducted to study the protective role of taurine against(More)
Methimazole and propylthiouracil have been used in the management of hyperthyroidism for more than half a century. However, hepatotoxicity is one of the most deleterious side effects associated with these medications. The mechanism(s) of hepatic injury induced by antithyroid agents is not fully recognized yet. Furthermore, there are no specific tools for(More)
Diabetes mellitus is a common endocrine disorder. Anti-diabetic agents from natural and synthetic sources are available for the treatment of this disease. Berberis integerrima is a medicinal shrub used in conventional therapy for a number of diseases. The aim of the present study was to investigate the effects of aqueous extract of Berberis integerrima root(More)
OBJECTIVE Diabetes mellitus is the most common metabolic disorders with severe impact on quality of life. Reducing serum glucose levels and normalization of serum lipid is of great clinical importance for treating diabetes. To our knowledge, there are not any evidences about the anti-diabetic action of capparis spinosa root. In the present study the effects(More)
Methimazole is the most widely prescribed antithyroid medication in humans. However, hepatotoxicity is a deleterious adverse effect associated with methimazole administration. No specific protective agent has been developed against this complication yet. This study was designed to investigate the role of taurine as a hepatoprotective agent against(More)
An experiment was conducted to study the effects of silver nanoparticles (AgNPs) on the contents of free amino acids, protein, lipid peroxidation (MDA) and antioxidant enzymes activity, viz., superoxide dismutase (SOD), catalase (CAT), peroxidase (POX) in tomato plants. For this purpose 20 nm size AgNPs in five different concentrations, viz., 0, 25, 50, 75(More)