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As the size of functional and structural MRI datasets expands, it becomes increasingly important to establish a baseline from which diagnostic relevance may be determined, a processing strategy that efficiently prepares data for analysis, and a statistical approach that identifies important effects in a manner that is both robust and reproducible. In this(More)
"Is there a biology of intelligence which is characteristic of the normal human nervous system?" Here we review 37 modern neuroimaging studies in an attempt to address this question posed by Halstead (1947) as he and other icons of the last century endeavored to understand how brain and behavior are linked through the expression of intelligence and reason.(More)
Total brain volume accounts for about 16% of the variance in general intelligence scores (IQ), but how volumes of specific regions-of-interest (ROIs) relate to IQ is not known. We used voxel-based morphometry (VBM) in two independent samples to identify substantial gray matter (GM) correlates of IQ. Based on statistical conjunction of both samples (N = 47;(More)
To further understanding of basic and complex cognitive functions, previous connectome research has identified functional and structural connections of the human brain. Functional connectivity is often measured by using resting-state functional magnetic resonance imaging (rs-fMRI) and is generally interpreted as an indirect measure of neuronal activity.(More)
Creativity has long been a construct of interest to philosophers, psychologists and, more recently, neuroscientists. Recent efforts have focused on cognitive processes likely to be important to the manifestation of novelty and usefulness within a given social context. One such cognitive process - divergent thinking - is the process by which one extrapolates(More)
BACKGROUND Neuropsychiatric systemic lupus erythematosus (NPSLE) is associated with increased morbidity and mortality. METHODS We used Diffusion Tensor Imaging (DTI) to assess white matter abnormalities in seventeen NPSLE patients, sixteen SLE patients without NPSLE, and twenty age- and gender-matched controls. RESULTS NPSLE patients differed(More)
We examined the relationship between structural brain variation and general intelligence using voxel-based morphometric analysis of MRI data in men and women with equivalent IQ scores. Compared to men, women show more white matter and fewer gray matter areas related to intelligence. In men IQ/gray matter correlations are strongest in frontal and parietal(More)
Many studies of creative cognition with a neuroimaging component now exist; what do they say about where and how creativity arises in the brain? We reviewed 45 brain-imaging studies of creative cognition. We found little clear evidence of overlap in their results. Nearly as many different tests were used as there were studies; this test diversity makes it(More)
That creativity and psychopathology are somehow linked remains a popular but controversial idea in neuroscience research. Brain regions implicated in both psychosis-proneness and creative cognition include frontal projection zones and association fibers. In normal subjects, we have previously demonstrated that a composite measure of divergent thinking (DT)(More)