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Because of previously observed species differences in rhein tolerability, with rabbits being very susceptible to kidney disturbances, in vivo and in vitro biotransformation studies were performed to find out whether the differences in the undesired effects of rhein are associated with qualitative, species-dependent differences in its metabolism. First hints(More)
The determination of the naphthodianthrone constituents in extracts of dried blossoms of Hypericum perforatum L. by combined HPLC-electrospray mass spectrometry is described. Hypericin (1), pseudohypericin (2) and their precursor compounds produce intensive negative quasi-molecular ions by deprotonation provided a non-acidic eluent system is used in the(More)
PHELIX is a Petawatt high-energy laser for heavy-ion experiments that can deliver 1-10 ns long pulses at 1053 nm with energies up to 1 kJ to the ion beam target chamber at the Z6 experimental area or 200 TW in sub-picosecond pulses to the target chamber in the laser bay. Near-term upgrades comprise frequency doubling of the ns pulses to 527 nm and a power(More)
There have been few descriptions extravasation into the superior vena cava and right atrium during intravenous DSA. This is seen almost exclusively when using straight catheters. The configuration of pigtail DSA catheters should reduce or prevent damage to vessel wall due to extravasation. Following an extravasation into the right atrium, which we ascribed(More)
HIV-positive Patients often suffer from the symptoms of accompanying diseases. Palliative radiation therapy of associated tumors leads to an improvement of the patient's condition. Particularly skin tumors, which give rise to pronounced itching and ulcerating, are eliminated fast and safe by radiation therapy. Between 1984 and 1988, 6 HIV patients with(More)
In 50 normal subjects flow velocity and direction on the portal vein was measured by ultrasonic duplex system. The measurements revealed at a mean diameter of 9.7 mm, a mean flow velocity of 15.2 +/- 2.6 cm/s, corresponding to a volume flow of 693 +/- 235 ml/min. Postprandially this increased to 880 +/- 269 ml/min. Inter-observer and day to day measurements(More)
One of the most important milestones of the PHELIX laser program was reached in January 2003, when the required Nova laser components from Lawrence Livermore National Laboratory (LLNL) arrived at GSI. The basis for the transfer was the agreement between the Department of Energy of the United States of America (DOE) and the Federal Ministry of Education and(More)
Duplex ultrasonography is a useful non-invasive means of investigating portal vein blood flow in cases of liver disease. A group of 50 selected consecutive patients with portal hypertension revealed a significant increase in portal vein diameter of 3.5 mm on average, and a significant decrease in mean flow rate of, on average, 3.1 cm/s, in comparison with a(More)