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- Publications
- Influence
Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action.
- Renuka Mani, Vijayakumar Natesan
- Chemistry, Medicine
- Phytochemistry
- 2018
In recent years, public and scientific interest in plant flavonoids has tremendously increased because of their postulated health benefits. This review was mainly focuses on the flavone chrysin… Expand
Clinical aspects of urea cycle dysfunction and altered brain energy metabolism on modulation of glutamate receptors and transporters in acute and chronic hyperammonemia.
- Vijayakumar Natesan, Renuka Mani, Ramakrishnan Arumugam
- Biology, Medicine
- Biomedicine & pharmacotherapy = Biomedecine…
- 1 July 2016
In living organisms, nitrogen arise primarily as ammonia (NH3) and ammonium (NH4(+)), which is a main component of the nucleic acid pool and proteins. Although nitrogen is essential for growth and… Expand
Neuroprotective effect of chrysin on hyperammonemia mediated neuroinflammatory responses and altered expression of astrocytic protein in the hippocampus.
- Renuka Mani, Vijayakumar Natesan, Ramakrishnan Arumugam
- Chemistry, Medicine
- Biomedicine & pharmacotherapy = Biomedecine…
- 1 April 2017
Neuroinflammation is an innate immune response in the central nervous system (CNS) against metabolic and pathogenic toxic wastes. The main hypothesis implies that a state of hyperammonemia which is… Expand
Effect of naringin on ammonium chloride-induced hyperammonemic rats: A dose-dependent study
- Ramakrishnan Arumugam, Vijayakumar Natesan, Renuka Mani
- Chemistry
- 1 September 2016
Abstract Introduction In mammals, ammonia is primarily a toxin that affects the central nervous system, leading to liver damage and urea cycle disorder. Increased accumulation of ammonia results in a… Expand
Molecular docking studies of natural compounds of naringin on enzymes involved in the urea cycle pathway in hyperammonemia
- Ramakrishnan Arumugam, Renuka Mani, Amalan Venkatesan, Senthilmurugan Sengamalai, Vijayakumar Natesan, S. Kim
- Chemistry
- 26 June 2020
Purpose: To investigate the anti-hyperammonemic activity of naringin by molecular docking via in silico studies.Methods: Urea cycle proteins were docked to the natural compound naringin as well as a… Expand