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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin

• Morgan D. Fullerton, Sandra Galic, +14 authors Gregory R Steinberg
• Nature Medicine
• 2013

The obesity epidemic has led to an increased incidence of nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes. AMP-activated protein kinase (Ampk) regulates energy homeostasis and is… (More)

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

• Justin D. Crane, Rengasamy Palanivel, +15 authors Gregory R Steinberg
• Nature Medicine
• 2015

Mitochondrial uncoupling protein 1 (UCP1) is enriched within interscapular brown adipose tissue (iBAT) and beige (also known as brite) adipose tissue, but its thermogenic potential is reduced with… (More)

Hyperglycemia- and hyperinsulinemia-induced alteration of adiponectin receptor expression and adiponectin effects in L6 myoblasts.

• Xiangping Fang, Rengasamy Palanivel, +4 authors G. J. Sweeney
• Journal of molecular endocrinology
• 2005

Adiponectin has been shown to regulate glucose and fatty acid uptake and metabolism in skeletal muscle. Here we investigated the role of the recently cloned adiponectin receptor (AdipoR) isoforms in… (More)

Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes.

• Rengasamy Palanivel, Xiangping Fang, +7 authors Gary Sweeney
• Cardiovascular research
• 2007

OBJECTIVE Our aim was to investigate the regulation of glucose and fatty acid metabolism in cardiomyocytes by the globular (gAd) and full-length (fAd) forms of adiponectin. METHODS We produced fAd… (More)

Distinct effects of short- and long-term leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes.

• Rengasamy Palanivel, Megumi Eguchi, Irina Shuralyova, Imogen R. Coe, G. J. Sweeney
• Metabolism: clinical and experimental
• 2006

Alterations in cardiac glucose and fatty acid metabolism are possible contributors to the pathogenesis of heart failure in obesity. Here we examined the effect of leptin, the product of the obese… (More)

Regulation of insulin signalling, glucose uptake and metabolism in rat skeletal muscle cells upon prolonged exposure to resistin

• Rengasamy Palanivel, Adriano Maida, Yi Ran Liu, G. J. Sweeney
• Diabetologia
• 2005

Debate exists regarding the role of resistin in the pathophysiology of insulin resistance. The aim of this study was to directly assess the effects of resistin (0–24 h) on basal and… (More)

Regulation of fatty acid uptake and metabolism in L6 skeletal muscle cells by resistin.

• Rengasamy Palanivel, G. J. Sweeney
• FEBS letters
• 2005

Resistin has been proposed as a potential link between obesity and insulin resistance. It is also well established that altered metabolism of fatty acids by skeletal muscle can lead to insulin… (More)

Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

• Sebastian Beck Jorgensen, Hayley M. O’Neill, +12 authors Gregory R Steinberg
• Diabetes
• 2013

Obesity is associated with chronic low-grade inflammation that contributes to defects in energy metabolism and insulin resistance. Suppressor of cytokine signaling (SOCS)-3 expression is increased in… (More)

Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice.

• Ying Yu Liu, Rengasamy Palanivel, +5 authors G. J. Sweeney
• Diabetes
• 2015

Numerous studies have characterized the antidiabetic effects of adiponectin, yet the precise cellular mechanisms in skeletal muscle, in particular, changes in autophagy, require further… (More)

Interleukin-15 Modulates Adipose Tissue by Altering Mitochondrial Mass and Activity

• Nicole G Barra, Rengasamy Palanivel, +12 authors Ali A Ashkar
• PloS one
• 2014

Interleukin-15 (IL-15) is an immunomodulatory cytokine that affects body mass regulation independent of lymphocytes; however, the underlying mechanism(s) involved remains unknown. In an effort to… (More)

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