Renee L. Killins

Learn More
Ligands for peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) increase skeletal muscle fatty acid catabolism, improve insulin sensitivity, increase serum high-density lipoprotein cholesterol, elicit anti-inflammatory activity and induce terminal differentiation. Contradictory findings are also reported suggesting that PPARbeta/delta(More)
There is considerable controversy regarding the effects of ligand activation of peroxisome proliferator-activated receptor-β (PPARβ) on cell growth. Some studies show that ligand activation of PPARβ leads to a decrease in cell proliferation and promotes differentiation. However, other work shows that ligand activation of PPARβ increases proliferation of(More)
Spleen tyrosine kinase (Syk) has been implicated in a number of pathologies including cancer and rheumatoid arthritis and thus has been pursued as a novel therapeutic target. Because of the complex relationship between Syk's auto- and other internal phosphorylation sites, scaffolding proteins, enzymatic activation state and sites of phosphorylation on its(More)
  • 1