Renee E. Yura

Learn More
A method is given for small-scale preparation of DNA from 1.0-1.5g of adult rat tissues. The product from brain or liver is characterized by base ratios and phosphorus content which accord with reported values for rat tissue. It is reasonably free of RNA, protein and glycogen. It contains 5-hydroxymethylcytosine at a content of about 15% of the total(More)
Meprin metalloproteases are highly expressed at the luminal interface of the intestine and kidney and in certain leukocytes. Meprins cleave a variety of substrates in vitro, including extracellular matrix proteins, adherens junction proteins, and cytokines, and have been implicated in a number of inflammatory diseases. The linkage between results in vitro(More)
Meprin metalloproteases, composed of alpha and/or beta subunits, consist of membrane-bound and secreted forms that are abundantly expressed in proximal tubules of the kidney as well as secreted into the urinary tract. Previous studies indicated that meprin metalloproteases play a role in pathological conditions such as ischemic acute renal failure and(More)
23 Meprin metalloproteases are highly expressed at the luminal interface of the intestine and 24 kidney and in certain leukocytes. Meprins cleave a variety of substrates in vitro including 25 extracellular matrix proteins, adherens junction proteins and cytokines, and have been 26 implicated in a number of inflammatory diseases. The linkage between results(More)
  • 1