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O(6)-Methylguanine DNA methyltransferase (MGMT) is implicated as a major predictive factor for treatment response to alkylating agents including temozolomide (TMZ) of glioblastoma multiforme (GBM) patients. However, whether the MGMT status in GBM patients should be detected at the level of promoter methylation or protein expression is still a matter of(More)
Background. Various supratentorial pathological conditions can mimic neoplastic cerebral lesions clinically as well as radiologically. Analysis of the neuroradiological findings, the clinical history, laboratory and other paraclinical data mostly help to narrow down the diagnosis of cerebral pathologies. Sometimes, however, histopathological analysis of the(More)
Although arachnoid granulations (AGs) were already described by Antonio Pacchioni more than 300 years ago, two issues draw particular attention: first, the radiological features and differential diagnosis of the so-called giant AGs (GAGs) and second, their possible association with various disease processes. In order to evaluate the frequency, size and(More)
The present paper deals with the application of atomic force microscopy (AFM) as a tool for morphological characterization of histological brain tumor samples. Data mining techniques will be applied for automatic identification of brain tumor tissues based on AFM images by means of classifying grade II and IV tumors. The rapid advancement of AFM in recent(More)
We present a cluster spatial analysis method using nanoscopic dSTORM images to determine changes in protein cluster distributions within brain tissue. Such methods are suitable to investigate human brain tissue and will help to achieve a deeper understanding of brain disease along with aiding drug development. Human brain tissue samples are usually treated(More)
Taking a look at actual developments in the field of bioinformatics, computer support in different fields of medicine and biology is an increasing field of interest. Especially for recognition and classification of various kinds of diseases, researchers already identified the usage of data mining techniques as supporting tool for computer supported analysis(More)
CLINICAL PRESENTATION On two consecutive days, two women, 82 and 76 years of age, were admitted with severe watery diarrhoea lasting for about 8 months. They presented with serious deconditioning and a weight loss of 16 and 20 kg, respectively. An extensive workup had yielded virtually identical results in both patients and led to the diagnosis of(More)
BACKGROUND Cervical cancer is causally related to cervical infections by oncogenic human papillomavirus (HPV) genotypes. To improve the quality of diagnosis evaluation of screening methods and their HPV type detection rate is an important part for this item. OBJECTIVES Two different cervical specimens of the same patients were analysed simultaneously with(More)