Rene B. Myburg

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Studies indicate that hyperglycemia-induced oxidative stress triggers the development of microvascular and macrovascular complications in diabetes. Accordingly, we hypothesized that maslinic acid (MA) prevents these complications due to its antioxidant properties. We, therefore, investigated the effects of 5-week MA treatment of streptozotocin (STZ)-induced(More)
Mycotoxins that commonly contaminate staple food grains pose a health hazard to animals and humans. Fumonisin B1 (FB1), a mycotoxin produced by Fusarium verticillioides, causes equine leukoencephalomalacia and porcine pulmonary edema and has been implicated in the etiology of esophageal cancer (EC) in the Transkei, South Africa. Various studies have(More)
PURPOSE Recent reports suggest that the hypoglycaemic effects of the triterpenes involve inhibition of glucose transport in the small intestine. Therefore, the effects of Syzygium spp-derived triterpenes oleanolic acid (OA) and maslinic acid (MA) were evaluated on carbohydrate hydrolyzing enzymes in STZ-induced diabetic rats and consequences on postprandial(More)
Introduction Cancer of the oesophagus (OC) follows the increasing incidence of cancer worldwide. There is a high incidence in the black population in certain parts of Transkei, South Africa and in parts of China; both have increased in recent times. Maize is the staple food of the population of Transkei. Fumonisins are mycotoxins produced by Fusarium(More)
The aim of the present study was to investigate the effects of methonolic extracts of Tulbaghia violacea (TVL), on Jurkat cells (human T lymphocyte). Jurkat cells were treated with IC50 concentrations of TVL (leaf, rhizome and stalk) extracts as determined by MTT assay and glutathione (GSH) concentration was measured using the GSH-Glo assay. The comet and(More)
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