Renaud Cezar

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Immune activation in HIV-1-infected individuals is reduced under antiretroviral therapies, but persists, resulting in various morbidities. To better characterize this phenomenon, using a panel of 68 soluble and cell surface markers, we measured the level of activation in circulating CD4+ and CD8+ T cells, B cells, monocytes, NK cells, polynuclear and(More)
A high prevalence of monoclonal gammopathy (MG) has been observed in HIV-infected patients. We explored the conditions associated with long-term persistence of serum monoclonal protein (M protein) in HIV-infected patients on antiretroviral therapy (ART). Of 21 patients with MG, M protein disappeared in 12 patients (58%) over 5 years of ART. Higher level of(More)
a Institute for Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, 34396, Montpellier, cedex 5, France b Infectious Diseases Department, University Hospital, 80 avenue A. Fliche, 34295 Montpellier, cedex 5, France c Institute for Functional Genomics, Montpellier University, UMR5203, 141 rue de la Cardonille, 34396 Montpellier, cedex 5, France d(More)
While significant work in data mining has been dedicated to the detection of single outliers in the data, less research has approached the problem of isolating a group of outliers, i.e. rare events representing micro-clusters of less – or significantly less – than 1% of the whole dataset. This research issue is critical for example in medical applications.(More)
OBJECTIVES To evaluate the potential implication of circulating endothelial cells (CECs) in complications following endovascular treatment (EVT) of unruptured intracranial aneurysms. CECs characterized as CD146(+)/CD105(+)/CD45(-)/DAPI(+) were considered to originate from an altered endothelial cell layer of the vessel wall. STUDY DESIGN In 15 patients,(More)
INTRODUCTION Interleukin-33 (IL-33) is a cell damage-induced alarmin. The plasma concentration of suppression of tumorogenicity (sST2), a surrogate marker of IL-33 production, is a prognostic marker of cardiovascular disease. OBSERVATION Recently, we reported that sST2 plasma levels were elevated in early HIV-1 infection and linked to markers of microbial(More)
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