Renato M. Fonseca

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Given a graph G and a positive integer k, we want to nd k spanning trees on G, not necessarily disjoint, of minimum total weight, such that the weight of each edge is subject to a penalty function if it belongs to more than one tree. We present a polynomial time algorithm for this problem; the algorithm's complexity is quadratic in k. We also present two(More)
This study was conducted to investigate the presence of Epstein-Barr virus (EBV) and human papillomavirus (HPV) and the promoter methylation status of the death-associated protein kinase (DAPK) gene in high-grade intraepithelial lesions. Viral infection was analyzed using polymerase chain reaction (PCR), and promoter methylation status was evaluated using(More)
Statistical modeling of links between genetic profiles with environmental and clinical data to aid in medical diagnosis is a challenge. Here, we present a computational approach for rapidly selecting important clinical data to assist in medical decisions based on personalized genetic profiles. What could take hours or days of computing is available(More)
It has been pointed out that supersymmetric extensions of the Standard Model can induce significant changes to the theoretical prediction of the ratio Γ (K → eν)/Γ (K → μν) ≡ RK , through lepton flavour violating couplings. In this work we carry out a full computation of all one-loop corrections to the relevant ν H+ vertex, and discuss the new contributions(More)
OBJECTIVE To evaluate whether use of comedication with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) influences the retention of tumor necrosis factor inhibitors (TNFi) in patients with spondyloarthritis (SpA). METHODS Patients with SpA from the Rheumatic Diseases Portuguese Register who started treatment with their first TNFi(More)
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