Renate Ohler

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The effect of calcitriol/1 alpha,25-dihydroxyvitamin D3, alone and in combination with cytokines, on the expression of various antigens (Ag) on human peripheral blood monocytes and U937 cells was studied by flow cytometry. Both constitutive and interferon-gamma (IFN-gamma), interleukin-4 (IL-4), IL-6 and tumour necrosis factor-alpha (TNF-alpha)-induced(More)
GM-CSF is widely used in combination with IL-4 to differentiate monocytes into potent T cell stimulatory cells, referred to as monocyte-derived dendritic cells (MoDC). These cytokines further increased the stimulatory function of MoDC when present during their incubation with antigen, as determined by the proliferative response of an allergen-specific T(More)
By A. A. KERHULAS, M.D., ROBERT L. OHLER, M.D., RICHARD WARREN, M.D. AND JOHN S. BELKO, M.S. V ENOUS THRGMBOSIS with its threat of pulmonary embolism is a constant c!angei’ following major surgical procedures. Of the three factors winic’h may predispose to this event, namely, venous stasis, injutt’y to f-he intima of the vein wall and alterations in the(More)
Carbohydrate antigens resulting from aberrant glycosylation of tumor cells, such as SialylTn, represent attractive targets for cancer vaccination. However, T-cell-independent carbohydrate antigens are poorly immunogenic and fail to induce memory and IgG class switch. Clustered expression patterns of some carbohydrates on the cell surface add further(More)