Renad Z. Sagdeev

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PURPOSE To determine age-related changes in the composition of the urea-soluble (US) protein fraction from lenses of senescence-accelerated OXYS (cataract model) and Wistar (control) rats and to establish posttranslational modifications (PTMs) occurring under enhanced oxidative stress in OXYS lenses. METHODS The identity and the relative abundance of(More)
The microbial community of the human gut has a crucial role in sustaining host homeostasis. High-throughput DNA sequencing has delineated the structural and functional configurations of gut metagenomes in world populations. The microbiota of the Russian population is of particular interest to researchers, because Russia encompasses a uniquely wide range of(More)
PURPOSE To determine the age-related and the cataract-specific changes in the crystallin composition in lenses of accelerated-senescence OXYS (cataract model) and Wistar (control) rats. METHODS The water soluble (WS) and insoluble (WIS) fractions of the lens proteins were separated; the identity and relative abundance of each crystallin in WS fraction(More)
Supplementation of senescence-accelerated OXYS rats with the mitochondria-targeted antioxidant SkQ1 and with the powder from Cistanche deserticola results in the deceleration of the cataract development and even in the improvement of lens transparency. The therapeutic effect of these preparations correlates with a significant elevation of tryptophan and(More)
The complex of Cu(2+) hexafluoroacetylacetonate with two pyrazol-substituted nitronyl nitroxides represents an unusual exchange-coupled three-spin system. The antiferromagnetic exchange coupling, which already atT < 150 K is larger than the thermal energy kT, induces the transition from a total spin state S = (3)/(2) to a state S = (1)/(2) and produces(More)
The analysis of post-mortem metabolomic changes in biological fluids opens the way to develop new methods for the estimation of post-mortem interval (PMI). It may also help in the analysis of disease-induced metabolomic changes in human tissues when the postoperational samples are compared to the post-mortem samples from healthy donors. The goals of this(More)
The ability of SkQ1 eye drops to slow down the cataract development is demonstrated on the senescence-accelerated OXYS rats: the SkQ1 treatment leads to the considerable improvement of the lens condition as compared to the control group. The comparison of the chaperone activities of α-crystallins isolated from the rat lenses did not reveal significant(More)
The complexes of Cu2+ hexafluoroacetylacetonate with two pyrazol-substituted nitronyl nitroxides are the choice systems to study the spin dynamics of strongly exchange-coupled spin triads. The large values of exchange coupling (ca. 100 cm-1) and high-resolution electron paramagnetic resonance (EPR) at Q- and W-bands (35 and 94 GHz) allowed us to observe and(More)
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