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Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats
TLDR
Testing the hypothesis that neurotrophic factors secreted by human bone marrow-derived MSCs promote endogenous neurogenesis, reduce apoptosis, and improve functional recovery after ischemia in rats suggests an essential role for hBMSCs. Expand
Overview of the health care system in Hong Kong and its referential significance to mainland China
TLDR
Under the framework of one country, two systems, the referential significance of relevant concepts of Hong Kong's medical service system to mainland China cannot be ignored, and merits further study. Expand
Diagnosis and management of pituitary abscess: experiences from 33 cases
TLDR
A review of patients treated for pituitary abscess at the Peking Union Medical College Hospital (PUMCH) found that the effectiveness of surgical and antibiotic therapies in determining the salient signs and symptoms of pituitaries abscess was questionable. Expand
Intra-Arterial Delivery of Human Bone Marrow Mesenchymal Stem Cells is a Safe and Effective Way to Treat Cerebral Ischemia in Rats
TLDR
Comparisons of the therapeutic effects of bone marrow stem cells delivered by intra-arterial (IA) and intravenous (IV) injection in a rat transient middle cerebral artery occlusion model are compared and showed that the IA route is a safe and effective way to transplant hBMSCs. Expand
Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macaca fascicularis
TLDR
Test the hypothesis that transplanted human bone-marrow-derived MSCs (hBMSCs) exert a neuroprotective effects on cerebral ischemia and upregulate IL-10 expression showed that hBMSC transplantation in ischemic tissues improved the neurological functions and induced an increase in IL- 10 expression. Expand
Angiopoietin 1 counteracts vascular endothelial growth factor-induced blood–brain barrier permeability and alleviates ischemic injury in the early stages of transient focal cerebral ischemia in rats
TLDR
In cerebral ischemia, the combination of Ang1 and VEGF could be used early to promote the formation of mature neovessels and protect the injured cells, without inducing the side effects on BBB permeability. Expand
STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion.
TLDR
Results indicate that adenoma GH hypersecretion is the result of STAT3-dependent GH induction, which in turn promotes STAT3 expression, and suggest STAT3 as a potential therapeutic target for pituitary somatotroph adenomas. Expand
Effects of bone marrow mesenchymal stromal cells on gross motor function measure scores of children with cerebral palsy: a preliminary clinical study.
TLDR
Autologous BM-MSC transplantation appears to be a feasible, safe and effective therapy for patients with CP and the treatment improved the development of children with CP with regard to motor function. Expand
CR1 rs3818361 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Chinese Population
TLDR
The findings indicate that the effect of CR1 rs3818361 polymorphism on AD risk in Chinese cohorts is consistent with the increased risk observed in European AD cohorts, and this is the first study to show significant association betweenrs3818 361 polymorphism and AD in Chinese population by a meta-analysis method. Expand
Quantitative protein profiling of hippocampus during human aging
TLDR
Substantial protein profile changes in the human hippocampus during aging are demonstrated, which could be of relevance to age-related loss of hippocampal functions. Expand
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