Renée S Marshall

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In contrast to the pattern of limb emergence in mammals, chicks, and the newt N. viridescens, embryos such as Xenopus laevis and Eleutherodactylus coqui initiate pelvic limb buds before they develop pectoral ones. We studied the expression of Pitx1 in X. laevis and E. coqui to determine if this paired-like homeodomain transcription factor directs(More)
While the cholinesterase-inhibiting N-methyl carbamate pesticides have been widely used, there are few studies evaluating direct functional and biochemical consequences of exposure. In the present study of the acute toxicity of seven N-methyl carbamate pesticides, we evaluated the dose-response profiles of cholinesterase (ChE) inhibition in brain and(More)
This study aimed to model long-term subtoxic human exposure to an organophosphorus pesticide, chlorpyrifos, and to examine the influence of that exposure on the response to intermittent high-dose acute challenges. Adult Long-Evans male rats were maintained at 350 g body weight by limited access to a chlorpyrifos-containing diet to produce an intake of 0, 1,(More)
HIV Tat is a viral transactivator that strongly stimulates the processivity of RNA polymerase II (RNAP II) via recruitment of the cyclin T1/CDK9 transcription elongation factor , which phosphorylates the C-teminal domain of RNAP II and negative elongation factors. We have investigated the effects of limiting CDK9 activity with recombinant lentiviruses(More)
Molinate, a thiocarbamate herbicide, has been reported to impair reproductive capability in the male rat and alter pregnancy outcome in a two-generation study. Published data are lacking on the effects of acute exposure to molinate in the female. Based on this work and our previous observations with related dithiocarbamate compounds, we hypothesized that a(More)
Reply to the letter from Workman et al. Sir-Workman et al. have provided a detailed critique on one of the implications of the data presented in our recent paper (Marshall et al., 1989), namely that the enzyme DT-diaphorase may play a role in the selection or design of chemotherapeutic agents aimed at controlling hypoxic tumour cell populations. We share(More)
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