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OBJECTIVE Use of antidepressants has been reported to cause considerable weight gain. The aim of this study was to assess the risk of diabetes mellitus associated with antidepressant treatment and to examine whether the risk is influenced by treatment duration or daily dose. METHOD This was a nested case-control study in a cohort of 165,958 patients with(More)
1 ABSTRACT The World Wide Web has since its beginning provided linking to and from text documents encoded in HTML. The Web has evolved and most Web browsers now support a rich set of media types either by default or by the use of specialised content handlers, known as plug-ins. The limitations of the Web linking model are well known and they also extend(More)
BACKGROUND A recent meta-analysis of randomized trials revealed that antiepileptic drugs (AEDs) as a class increase the risk of suicidal thoughts and behavior. We conducted an observational study with data from the United Kingdom General Practice Research Database to investigate if an increase in risk for different groups of AEDs is also evident in clinical(More)
BACKGROUND AND PURPOSE Several randomized trials and a large number of epidemiological studies have provided evidence of an increased risk of acute myocardial infarction associated with the use of cyclooxygenase (COX)-2 selective nonsteroidal anti-inflammatory drugs (NSAIDs). Few data are available concerning the risk of ischemic stroke associated with(More)
BACKGROUND Data on utilization patterns and safety of non-steroidal anti-inflammatory drugs (NSAIDs) in children are scarce. The purpose of this study was to investigate the utilization of NSAIDs among children in four European countries as part of the Safety Of non-Steroidal anti-inflammatory drugs (SOS) project. METHODS We used longitudinal patient data(More)
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