René R. P. de Vries

Learn More
 In the present study, we tested our hypothesis on the role of a DQ-DR haplotype in rheumatoid arthritis (RA) predisposition. Using two groups of patients and controls, one from The Netherlands and one from Switzerland, we found that DQA1*0301-homozygous and DQA1*0301//DQA1*0101/04-heterozygous individuals are highly predisposed to RA in both populations,(More)
Thucydides recognized not only the occurrence of acquired immunity but also that susceptibility for or ability to recover from an infectious disease differs between individuals. This difference between individuals can have many causes: age, nutritional status, religion but also genetic make-up. It is this latter aspect that we want to discuss. It has been(More)
Aims/hypothesis. Type I (insulin-dependent) diabetes mellitus is a T-cell mediated autoimmune disease. Several subsets of T-cells, in particular CD4+ and in vivo activate CD45RA+RO+ T-cells, have been shown to be increased at disease onset. The functional implications of these relative increases in CD4 T-cells were investigated. Methods. Subsets of T-cells(More)
In order to identify better markers for HLA-DR4-associated autoimmune disorders, we have studied the complexity of the HLA class II region in DR4-positive cells at the DNA level and compared the DNA polymorphism with that defined by serology, mixed lymphocyte culture (MLC) reactivity, and protein chemistry. At the DNA level, HLA-DR4 can be characterized by(More)
HLA-DR molecules were isolated from HLA-DR3, −5, and −w6 positive homozygous B-cell lines by immunoprecipitation with monoclonal antibodies and analyzed by gel electrophoretic techniques. DNA isolated from the same cell lines was digested with the restriction enzyme Taq I and hybridized with a DR beta full-length cDNA probe. We demonstrated that certain DR(More)
We established the detailed polymorphism of the 5′-flanking region and the first exon of the human leukocyte antigen (HLA)-DQB1 alleles. One hundred and forty-five Spanish rheumatoid arthritis (RA) patients and 200 healthy voluntary blood donors from southern Spain along with 42 B-cell lines were analyzed for the presence of the retrovirus-derived long(More)
Although there have been many years of intense research into the biochemical, genetic, microbiological, and immunological aspects of rheumatoid arthritis (RA), its pathogenesis is not completely understood and its treatment does not succeed in stopping the progression of joint destruction. It is generally accepted that RA is a systemic, inflammatory disease(More)
T cells and antibodies against self and non-self hsp are present in both patients and healthy controls. T cells responding to hsp65 can be involved in autoimmune diseases, this was demonstrated for two site-specific animal autoimmune diseases: AA in Lewis rats and diabetes (IDDM) in NOD mice. In human ReA there is evidence for a direct stimulation of joint(More)
In most individuals extensive exposure to mycobacteria does not result in disease [21]. Many factors are involved in this apparent successful parasitism of mycobacteria. For instance, most mycobacterial species rarely or never cause disease. In this chapter we will only discuss genetic host factors that play a role in the outcome of an infection with(More)
The HLA-DRB group of ‘DR52’ related alleles encode the DR3, DR5, DR6, and DR8 antigens. With molecular techniques almost 150 different DRB1 alleles and 11 DRB3 alleles can now be distinguished (Bodmer et al. 1997). An irregular typing was observed when a Dutch Caucasoid individual, GVDP, serologically characterized as A2/A24(9) B51(5)/B15 DR1/DR6, typed as(More)