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Because thrombin-induced inflammation is partially mast cell-dependent and involves proteinase-activated receptors (PARs), we hypothesized that mast cells express PAR and can be stimulated with PAR-activating peptides (PAR-AP). We demonstrated that rat peritoneal mast cells expressed PAR-1 and PAR-2 mRNA, and that PAR-2AP (tc-LIGRLO-NH(2), 1 microm) induced(More)
Viral infections play an important role in the exacerbation of asthma. The production of interferons (IFNs) is well known to limit viral spread, but IFN-␥ can also prime alveolar macrophages to release more inflam-matory cytokines, such as tumor necrosis factor-␣ (TNF-␣) and macrophage inflammatory protein-1 ␣ (MIP-1 ␣). Given the importance of these(More)
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