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  • Ingo Rekittke, Jochen Wiesner, +10 authors Ulrich Ermler
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • 2008 (First Publication: 24 December 2008)
  • Molecular evolution has evolved two metabolic routes for isoprenoid biosynthesis: the mevalonate and the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. The MEP pathway is used by most pathogenicContinue Reading
  • René C Röhrich, Nadine Englert, +11 authors Jochen Wiesner
  • Medicine, Biology
  • FEBS letters
  • 2005 (First Publication: 21 November 2005)
  • In the malaria parasite Plasmodium falciparum isoprenoid precursors are synthesised inside a plastid-like organelle (apicoplast) by the mevalonate independent 1-deoxy-d-xylulose-5-phosphate (DOXP)Continue Reading
  • Philipp Simon, Sören Bäumner, +11 authors Sebastian P Galuska
  • Biology, Medicine
  • The Journal of biological chemistry
  • 2013 (First Publication: 28 June 2013)
  • Fertilization in animals is a complex sequence of several biochemical events beginning with the insemination into the female reproductive tract and, finally, leading to embryogenesis. Studies byContinue Reading
  • Steven Van Hoof, Carl Jeffrey Lacey, René C Röhrich, Jochen Wiesner, Hassan Jomaa, Serge van Calenbergh
  • Chemistry, Medicine
  • The Journal of organic chemistry
  • 2008 (First Publication: 1 February 2008)
  • (E)-1-Hydroxy-2-methyl-but-2-enyl 4-diphosphate (HMBPP) is an intermediate in the non-mevalonate pathway for the biosynthesis of isoprenoids and also serves as a very strong activator of human gammaContinue Reading