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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation
The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverseExpand
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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI). Clearance of SCs in a progeroid mouse model using a transgenic approach delays severalExpand
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A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics
Pseudogenes are thought to be inactive gene sequences, but recent evidence of extensive pseudogene transcription raised the question of potential function. Here we discover and characterize the setsExpand
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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
Senescent cells (SnCs) accumulate in many vertebrate tissues with age and contribute to age-related pathologies, presumably through their secretion of factors contributing to theExpand
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Lamin B1 loss is a senescence-associated biomarker
This study rigorously defines lamin B1 loss as a marker of senescence in response to all classic signals of senescence, including DNA damage, oncogene activation, and replicative exhaustion. ThisExpand
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Senescent cells: an emerging target for diseases of ageing
Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-relatedExpand
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Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype
Cellular senescence suppresses cancer by arresting the proliferation of cells at risk for malignant transformation. Recently, senescent cells were shown to secrete numerous cytokines, growth factors,Expand
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Epithelial-Mesenchymal Transition Induced by Senescent Fibroblasts
Depending on the cell type and tissue environment, epithelial and mesenchymal cell phenotypes are not static and can be highly dynamic. Epithelial-mesenchymal transitions (EMTs) and reverse EMTsExpand
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p53: Pro-aging or pro-longevity?
p53 continues to surprise biologists. For nearly a decade, it was thought to be an oncogene [1,2], only to be subsequently declared a potent tumor suppressor [3,4]. Initially characterized as aExpand
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Age-Related Neurodegeneration Prevention Through mTOR Inhibition: Potential Mechanisms and Remaining Questions.
With the global aging population, Alzheimer's disease, Parkinson's disease and mild cognition impairment are increasing in prevalence. The success of rapamycin as an agent to extend lifespan inExpand
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