Relja Kovacevic

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Aim of the study is to determine the possible roles of p53, cyclin D1, β-catenin and Ki-67 in the increase in risk of fractures in patients with giant cell tumor of bone. The study included a total of 164 patients with giant cell tumor of bone (GCTB), 21 (12.8%) with and 143 (87.2%) without fracture. The samples were analyzed immunohistochemically for(More)
Three newly synthesized copper complexes with pyridoxal semicarbazone (PLSC), as ligand, after being subjected to biological tests, showed anticancer activity. As ligand PLSC is biologically active, the results of biological activity are as expected. Specifically, an activity was demonstrated in breast cancer cells (MCF7 and MDA MB 231) and proliferative(More)
To determine various clinical, radiographic, and pathological parameters which may indicate an increased risk of Giant cell tumour of bone (GCTB) recurrence after surgical therapy. The study included a total of 164 GCTB samples; 118 (72 %) primary tumours, and 46 (28 %) recurrences; which were analyzed on immunohistochemistry for expression of Ki67, p53,(More)
Modern radiation cytogenetics has adopted the principle that DNA molecule as an essential biological substrate is the most important target of ionizing radiation. This action may result in delicate lesions of the hereditary material that may be manifested in the form of structural chromosomal aberrations. This study present results of years of cytogenetic(More)
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