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Interstitial cells (ICs) play a role in regulating normal bladder activity. This study explores the possibility that the sub-urothelial and muscle networks of NO/cGMP-responsive ICs are altered in animals with surgically induced outflow obstruction. In sham-operated animals, the urothelium comprised NO-stimulated cGMP-positive (cGMP+) umbrella cells, an(More)
Rationale: Recently, a new putative animal model of anxiety, "light-enhanced startle" was introduced. By placing a rat in a brightly lit environment, which is a naturally aversive stimulus to rats, the amplitude of the startle response to a startle-eliciting noise burst is increased. Objectives: The present study aimed to determine the predictive validity(More)
Angiotensin-converting enzyme (ACE) is considered as a possible marker for endothelial cell damage in serum or bronchoalveolar lavage fluid. This hypothesis was tested during cardiac surgery and during the adult respiratory distress syndrome. We used patients with an expected different degree of endothelial cell damage. ACE levels in serum and(More)
THE IMMUNE SYSTEM PLAYS A CENTRAL ROLE BEFORE AND DURING PARTURITION, INCLUDING THE MAIN PHYSIOLOGICAL PROCESSES OF PARTURITION: uterine contractions and cervical ripening. The immune system comprises white blood cells and their secretions. Polymorphonuclear cells and macrophages invade the cervical tissue and release compounds, such as oxygen radicals and(More)
The presence of histamine and tryptase in serum during and after coronary artery bypass grafting may be an indication for the induction of inflammation. One group of patients received no glucocorticoids, a second one received methylprednisolone before extracorporeal circulation. In the steroid group, no effects were seen on the basal levels of histamine and(More)
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