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BACKGROUND It has been hypothesized that the Outcomes of DNA testing (O) are better predicted and/or mediated by the counselees' Perception P) than by the actually communicated genetic Information (I). In this study, we aimed at quantifying the effect that perception has in genetic counseling for hereditary breast/ovarian cancer. METHODS Two hundred and(More)
Using an accelerated longitudinal design, the development of externalizing problems from age 2 to 5 years was investigated in relation to maternal psychopathology, maternal parenting, gender, child temperament, and the presence of siblings. The sample consisted of 150 children selected at age 2-3 years for having high levels of externalizing problems.(More)
—The Netherlands Forensic Institute and the Institute for Forensic Science in Shanghai are in search of a signature verification system that can be implemented in forensic casework and research to objectify results. We want to bridge the gap between recent technological developments and forensic casework. In collaboration with the German Research Center for(More)
The authors show how the use of inequality constraints on parameters in structural equation models may affect the distribution of the likelihood ratio test. Inequality constraints are implicitly used in the testing of commonly applied structural equation models, such as the common factor model, the autoregressive model, and the latent growth curve model,(More)
The heritability of sensation seeking is investigated in an extended twin design, including mono- and dizygotic twins and their siblings. Besides a comparison of the phenotypic resemblance between monozygotic twins and dizygotic twins, the design allows for an explicit test of the assumption that results from twins may be generalized to the singleton(More)
Previous studies on the counsellees' perception of DNA test results did not clarify whether counsellees were asked about their recollections or interpretations, and focused only on patients' own risks and not on the likelihood that cancer is heritable in the family. We tested differences and correlations of four perception aspects: recollections and(More)
Este trabajo investiga las diferencias entre la regresión multinivel estándar y el modelo Abstract This paper investigates the differences between the standard multilevel regression and structural equation modeling framework regarding growth curve analysis. The basic growth curve model has the same specification in both frameworks, but in many instanc s(More)
Within the latent growth curve model, time-invariant covariates are generally mod-eled on the subject level, thereby estimating the effect of the covariate on the latent growth parameters. Incorporating the time-invariant covariate in this manner may have some advantages regarding the interpretation of the effect but may also be incorrect in certain(More)
To investigate underlying learning mechanisms in relation to the development of dyslexia, event-related potentials to visual standards were recorded in five-year-old pre-reading children at-risk for familial dyslexia (n=24) and their controls (n=14). At the end of second grade the children aged 8 years were regrouped into three groups according to literacy(More)