Reinier van der Linden

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To characterize the changes in axonal function in the motor and somatosensory tracts of the cord after spinal cord injury (SCI) and to correlate these changes with spinal cord blood flow (SCBF), the relationships among the severity of SCI, motor and somatosensory evoked potentials (MEPs and SSEPs) and SCBF were examined. Fifteen rats received a 1.5 g (n =(More)
There is evidence that posttraumatic ischemia is important in the pathogenesis of acute spinal cord injury (SCI). In the present study spinal cord blood flow (SCBF), measured by the hydrogen clearance technique, and motor and somatosensory evoked potentials (MEP and SSEP) were recorded to evaluate whether the administration of nimodipine and dextran 40,(More)
Thirty-two pediatric patients presenting with symptoms of urinary dysfunction, stool incontinence and/or severe back and/or leg pain are described. In patients with urological dysfunction, urodynamic testing was consistent with a neurogenic etiology. Imaging studies demonstrated the tip of the conus medullaris to lie above the L2 vertebral body, and the(More)
The human auditory steady-state evoked potentials were examined during several different tasks requiring attention. Both Fourier analysis and signal averaging were used to measure the responses at stimulus rates between 37 and 41/sec. There was no effect of attention on the amplitude and phase of the steady-state evoked potentials when subjects either(More)
Recent work has indicated that direct-current (DC) fields may promote recovery after acute spinal cord injury. In the present experiments, the therapeutic value of an applied DC field was studied in 40 rats with clip compression injuries of the cord at C7-T1. The rats were randomly allocated to one of four groups including 10 rats each: two groups received(More)
The human auditory steady state evoked potentials were recorded during all-night sleep in 10 subjects. The effects of stimulus rate and intensity on these potentials were measured using on-line Fourier analysis. The amplitude of the response was greatest at stimulus rates of 30 to 50/sec. Although the response amplitude was lower during sleep, the rate at(More)
OBJECT The authors conducted a study to provide an objective electrophysiological assessment of descending motor pathways in rats, which may become a means for predicting outcome in spinal cord injury research. METHODS Transcranial magnetic motor evoked potentials (TMMEPs) were recorded under various conditions in awake, nonanesthetized, restrained rats.(More)
The effects of the various anesthetic agents on the production of transcranial magnetic motor evoked potentials (tcMMEP) were studied in a canine model. Pre-anesthetic baseline tcMMEPs demonstrated consistency in onset latency measurements and variability in measurement of peak-to-peak amplitudes. Changes in tcMMEPs were evaluated following the individual(More)
Spinal cord monitoring using SSEPs is an accepted adjunct in the surgical correction of spinal deformities, but does not directly assess motor function. Motor-evoked potentials have been introduced in an effort to meet this important need. In this series of 18 patients, the feasibility of intraoperative monitoring using transcranial magnetic motor-evoked(More)
A need exists for an accurate neurophysiological technique that monitors the motor tracts of the cord in patients with spinal cord injury or other cord lesions and for the evaluation of experimental models of cord injury. We have recorded and characterized the motor evoked potentials (MEPs) from 10 normal rats and from 10 rats with the following cord(More)