Reinhold Weber

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BACKGROUND We report on 4 patients (aged 57 to 77 years; 3 men) who developed drug-refractory, repetitive ventricular tachyarrhythmias after acute myocardial infarction (MI). All episodes of ventricular arrhythmias were triggered by monomorphic ventricular premature beats (VPBs) with a right bundle-branch block morphology (RBBB). METHODS AND RESULTS Left(More)
BACKGROUND Experimental data suggest that use of cryoablation in pulmonary vein isolation (PVI) is associated with less cell damage and less thrombus formation compared to radiofrequency (RF) energy. OBJECTIVE The purpose of this study was to test the hypothesis that cryoablation significantly reduces markers of cell damage, platelet activation, and(More)
Heterozygous mutations in the cardiac homeobox gene, NKX2-5, underlie familial cases of atrial septal defect (ASD) with severe atrioventricular conduction block. In this study, mice heterozygous for Nkx2-5-null alleles were assessed for analogous defects. Although ASD occurred only rarely, atrial septal dysmorphogenesis was evident as increased frequencies(More)
BACKGROUND Pulmonary vein (PV) isolation is a promising new treatment for atrial fibrillation (AF). We hypothesized that isolation of large areas around both ipsilateral PVs with verification of conduction block is more effective than the isolation of each individual PV. METHODS AND RESULTS A total of 110 patients, 67 with paroxysmal AF and 43 with(More)
AIMS An increasing body of evidence has demonstrated the essential role of inflammation in the genesis and maintenance of atrial fibrillation (AF). The aim of the present study was to investigate whether success or failure of electrical pulmonary vein isolation (PVI) in patients with AF is related with the presence of a pre-ablative inflammatory state as(More)
BACKGROUND Pulmonary vein (PV) isolation using a balloon-mounted cryoablation system is a new technology for the percutaneous treatment of atrial fibrillation (AF). Transesophageal echocardiography (TEE) allows real-time visualization of cryoballoon positioning and successful vein occlusion via color Doppler. We hypothesized that PV mechanical occlusion(More)
BACKGROUND Obesity is a well established risk factor for atrial fibrillation (AF) development. Our purpose was to determine the impact of body mass index (BMI) on the safety and efficacy of radiofrequency catheter ablation of AF. METHODS Two hundred and twenty-six consecutive patients with symptomatic, drug-refractory paroxysmal (59.3%) and persistent(More)
AIMS The present study investigated whether several ECG markers of ventricular repolarization are associated with ventricular tachycardia/fibrillation (VT/VF) inducibility in subjects with type 1 ECG pattern of Brugada syndrome (BS). METHODS AND RESULTS The clinical data of 23 individuals (19 males, age 42.69 +/- 14.63) with spontaneous (n = 10) or(More)
OBJECTIVE The authors investigated correlations of estrogen-receptor and progesterone-receptor with conventional risk factors as well as histopathology in patients with primary breast cancer. SUMMARY BACKGROUND DATA Immunohistochemically determined hormone receptors have gained importance as prognosticators in primary breast cancer, but their definitive(More)
Neurons of T2 to T4 spinal segments were antidromically activated from the medullary reticular formation and the contralateral region in or near the ventral posterior lateral nucleus of the thalamus. Sixty-seven percent of the spinoreticular neurons projected to the ipsilateral, contralateral, or both ipsilateral and contralateral medullary reticular(More)