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  • Anne T Nies, Hermann Koepsell, +7 authors Elke Schaeffeler
  • Medicine, Biology
  • Hepatology
  • 2009 (First Publication: 1 October 2009)
  • UNLABELLED An important function of hepatocytes is the biotransformation and elimination of various drugs, many of which are organic cations and are taken up by organic cation transporters (OCTs) ofContinue Reading
  • Mikko Niemi, Elke Schaeffeler, +9 authors Kari T. Kivistö
  • Biology, Medicine
  • Pharmacogenetics
  • 2004 (First Publication: 1 July 2004)
  • This study aimed to characterize possible relationships between polymorphisms in the drug transporter genes organic anion transporting polypeptide-C (OATP-C, SLCO1B1), OATP-B (SLCO2B1), multidrugContinue Reading
  • Raimund Sprenger, Robert Schlagenhaufer, +4 authors Ulrich Brinkmann
  • Biology, Medicine
  • Pharmacogenetics
  • 2000 (First Publication: 1 August 2000)
  • Glutathione S-transferase theta enzyme activity involved in the metabolism of toxic compounds is absent in approximately 20% of Caucasians due to a homozygous deletion of GSTT1 (*0/0). Because theContinue Reading
  • Jürgen Brockmöller, Ingolf Cascorbi, Reinhold Kerb, Ivar Roots
  • Medicine
  • Cancer research
  • 1996 (First Publication: 1 September 1996)
  • Foreign compound-metabolizing enzymes may modify the risk of chemically induced cancer. We wanted to examine enzymes with putative relevance in urinary bladder cancer using molecular genetic analysesContinue Reading
  • Matthias Schwab, Ulrich M. Zanger, +9 authors Michel F Eichelbaum
  • Medicine
  • Journal of clinical oncology : official journal…
  • 2008 (First Publication: 1 May 2008)
  • PURPOSE To assess the predictive value of polymorphisms in dihydropyrimidine dehydrogenase (DPYD ), thymidylate synthase (TYMS ), and methylene tetrahydrofolate reductase (MTHFR ) and of nongeneticContinue Reading
  • Wiebke Solass, Reinhold Kerb, +6 authors Marc André Reymond
  • Medicine
  • Annals of Surgical Oncology
  • 2013 (First Publication: 5 September 2013)
  • AbstractBackgroundPeritoneal carcinomatosis (PC) is an unmet medical need. Despite recent improvements, systemic chemotherapy has limited efficacy. We report the first application of intraperitonealContinue Reading
  • Carmen Lang, Yvonne Meier, +6 authors Christiane Pauli-Magnus
  • Biology, Medicine
  • Pharmacogenetics and genomics
  • 2007
  • OBJECTIVES Increasing evidence suggests that a genetically determined functional impairment of the hepatocellular efflux transporters bile salt export pump (BSEP, ABCB11) and multidrug resistanceContinue Reading