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OBJECTIVE To analyze the results of 45 patients after ankle arthrodesis in the presence of joint infection. METHODS Arthrodesis was performed with two compression screws and an anterior plate in 29 patients and with two compression screws only in 16 patients. In all patients, additional stabilization with external fixation was used. In 29 patients,(More)
A dysbalanced immune response is thought to account for a substantial part of the morbidity and mortality after severe trauma. The cytokine interleukin-10 (IL-10) suppresses the transcription of proinflammatory cytokines, mainly in macrophages and monocytes. The objectives of this prospective study in a level I trauma center in Germany were to examine the(More)
OBJECTIVE To examine the influence of genetic variations in heat shock proteins on trauma outcome. DESIGN Prospective, noninterventional, single-center study. SETTING Level I trauma center. SUBJECTS Eighty consecutive severe multiple trauma patients. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Plasma concentrations of interleukin-6 and tumor(More)
BACKGROUND Acute respiratory failure is a common, life-threatening complication after severe trauma. Polymorphisms in cytokine genes, linked to cytokine inducibility, may influence the susceptibility to acute respiratory failure and serve as risk predictors. METHODS This PROSPECTIVE cohort study (n = 100) included Caucasian multiple trauma (Injury(More)
BACKGROUND Low circulating plasma concentrations of the leukocyte adhesion molecule L-selectin (sCD62L) were found to be associated with an increased risk for subsequent lung failure and case fatality after severe trauma. The objective of this study was to determine the robustness of soluble L-selectin, correcting for a broad spectrum of physiological(More)
In a prospective study, 53 fractures of the distal fifth of the tibia were stabilized by unreamed nailing. Additional involvement of the ankle joint occurred in 18 patients. 50 patients returned for follow-up. In 30 patients tibia and fibula were fractured at the same (distal) level; in 20 patients the fracture of the fibula was located more proximally. In(More)
The arterial ketone body ratio is calculated as the ratio of arterial levels of acetoacetate/beta-hydroxybutyrate. It correlates with survival in experimental hemorrhagic shock and outcome after liver surgery and myocardial infarction. Procedures for determination of ketone bodies are often laborious and unreliable. As yet the relationship between results(More)
Dysbalance in the immune system is perceived as a major factor for adverse outcome after trauma. Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that regulates proliferation, differentiation of cells, wound healing, and angiogenesis. The influence of TGF-beta1 on trauma patients outcome is still unclear. Injury patterns and(More)
Hospital medical activities are performed in various departments, such as general wards, functional units, outpatients' departments (OPD), and administrative areas. This study examined the possibility of redistributing medical performances from a normal ward to an OPD for an average accident surgery population. It is shown that up to 89% of the medical(More)