Reinhold Alexander Laun

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OBJECTIVE To analyze the results of 45 patients after ankle arthrodesis in the presence of joint infection. METHODS Arthrodesis was performed with two compression screws and an anterior plate in 29 patients and with two compression screws only in 16 patients. In all patients, additional stabilization with external fixation was used. In 29 patients,(More)
A dysbalanced immune response is thought to account for a substantial part of the morbidity and mortality after severe trauma. The cytokine interleukin-10 (IL-10) suppresses the transcription of proinflammatory cytokines, mainly in macrophages and monocytes. The objectives of this prospective study in a level I trauma center in Germany were to examine the(More)
Zur Untersuchung der Frage, in welcher Hinsicht ein mehrdimensionales bildgebendes Verfahren konventionellen Röntgenbildern bei der Diagnostik multiplanarer Übergangsfrakturen überlegen ist, wurde in einem Zeitraum von 18 Monaten bei 15 Frakturen im Bereich der distalen Tibia, bei denen im konventionellen Röntgenbild der Verdacht auf eine(More)
OBJECTIVE To examine the influence of genetic variations in heat shock proteins on trauma outcome. DESIGN Prospective, noninterventional, single-center study. SETTING Level I trauma center. SUBJECTS Eighty consecutive severe multiple trauma patients. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Plasma concentrations of interleukin-6 and tumor(More)
Dysbalance in the immune system is perceived as a major factor for adverse outcome after trauma. Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that regulates proliferation, differentiation of cells, wound healing, and angiogenesis. The influence of TGF-beta1 on trauma patients outcome is still unclear. Injury patterns and(More)
In a prospective study, 53 fractures of the distal fifth of the tibia were stabilized by unreamed nailing. Additional involvement of the ankle joint occurred in 18 patients. 50 patients returned for follow-up. In 30 patients tibia and fibula were fractured at the same (distal) level; in 20 patients the fracture of the fibula was located more proximally. In(More)
The arterial ketone body ratio is calculated as the ratio of arterial levels of acetoacetate/β-hydroxybutyrate. It correlates with survival in experimental hemorrhagic shock and outcome after liver surgery and myocardial infarction. Procedures for determination of ketone bodies are often laborious and unreliable. As yet the relationship between results from(More)
BACKGROUND Acute respiratory failure is a common, life-threatening complication after severe trauma. Polymorphisms in cytokine genes, linked to cytokine inducibility, may influence the susceptibility to acute respiratory failure and serve as risk predictors. METHODS This PROSPECTIVE cohort study (n = 100) included Caucasian multiple trauma (Injury(More)
In a prospective study, 53 fractures of the distal fifth of the tibia were stabilized by unreamed nailing. Additional involvement of the ankle joint occurred in 18 patients. 50 patients returned for follow-up. In 30 patients tibia and fibula were fractured at the same (distal) level; in 20 patients the fracture of the fibula was located more proximally. In(More)
In severe motorcyclist accidents unstable injuries of the cervical spine can usually not be excluded before an X-ray has been taken in the hospital. Despite this the helmet has to be taken off at the place of the accident in order to provide adequate treatment and airway management of the injured driver. There are no data in the current literature showing(More)