Reinhard Mielke

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Congenital cerebral defects can be classified into two groups of porencephaly. Agenetic porencephaly results from development disturbances during early neuronal migration and can often be observed in the region of the fissura Sylvii. Encephaloclastic porencephaly, which is relatively rare, is a late prenatal or perinatal vascular lesion due to arterial(More)
The first reported case of lissencephaly resulting from a consanguinous union strengthens the supposition that in some cases, it is transmitted as an autosomal recessive trait. Comparison of this case with a sporadically occurring case of lissencephaly, with different cortical morphology, suggests that lissencephaly may be an example of either varying gene(More)
Seizures in the newborn are a distinctive sign of underlying disease. Different convulsive patterns are described. The most common neurologic syndrome consists of subtle seizures. The most important cause is ischemic encephalopathy. Hypocalcemia is the main metabolic disease. Hypoglycemia seems not to be of special relevance for pathogenesis of newborn(More)
Two cases of lissencephaly syndrome type II are reported. Lissencephaly (smooth brain) is caused by a disorder of neuronal migration resulting in connatal hydrocephalus and lack of gyri as well as developmental abnormalities of the eye and muscles. Embryological relationships between these malformations and clinical appearances are described.
BACKGROUND The abuse of synthetic cannabinoids (SCs) as presumed legal alternative to cannabis poses a great risk to public health. For economic reasons many laboratories use immunoassays (IAs) to screen for these substances in urine. However, the structural diversity and high potency of these designer drugs places high demands on IAs regarding(More)
AIMS Compulsory admissions according to section sign 64 German penal code are rising. There is also a dramatic increase in dropout-rates with regard to coercive therapeutic interventions in forensic facilities specialized in the treatment of offenders addicted to drugs or alcohol. METHODS By means of two case histories dilemmas of expert opinion and(More)
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