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Wallerian degeneration was studied in the phrenic or sciatic nerves of mice following transplantation into Millipore diffusion chambers of 0.22 micron pore size which were implanted in the peritoneal cavity and kept for up to eight weeks. This method positively eliminates the access of nonresident cells to the tissue, at the same time providing proper(More)
Electron microscopic data on human bridging veins show thin walls of variable thickness, circumferential arrangement of collagen fibres and a lack of outer reinforcement by arachnoid trabecules, all contributory to the subdural portion of the vein being more fragile than its subarachnoid portion. These features explain the laceration of veins and the(More)
The significance of internode length for sheath thickness was analyzed by electron microscopic morphometry in isolated internodes from the human roots C3 and S1. These populations differ in length but have similar caliber. The amount of myelin per internode was in linear relation with the product of axon circumference and the length of the ensheathed axon(More)
Myelin phagocytosis in Wallerian degeneration of peripheral nerves depends on invasion of nerves by non-resident macrophages. The present study was done to clarify the role of the macrophage complement receptor type 3 (CR3) in myelin removal. Myelin phagocytic capacity of invading macrophages was abolished by treatment of cultured nerves and macrophages(More)
Counts of nuclei in electron micrographs of rat sciatic nerve show that approximately one third of the nuclear population is fibroblasts. Comparison of these figures with counts in teased fibers indicates that the majority of fibroblasts adheres tightly to myelinated nerve fibers. The early reactions and cellular transformations of the endoneurial(More)
(1) The length of the human ventral spinal roots in the newborn and in the adult were compared with the length of the internodes in these roots. Internodes of fibers of a given caliber were more than twice as long in the adult sacral roots than in the cervical roots. The factors of root elongation corresponded closely to the factors of internode elongation.(More)