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Wild-type p53 has a major role in the response and execution of apoptosis after chemotherapy in many cancers. Although high levels of wild-type p53 and hardly any TP53 mutations are found in testicular cancer (TC), chemotherapy resistance is still observed in a significant subgroup of TC patients. In the present study, we demonstrate that p53 resides in a(More)
The junctional neoplastic tumour suppressors, Lgl, Dlg and Scrib, function in apical-basal cell polarity and limiting cell proliferation. In homozygous lgl, dlg or scrib mutants over-proliferation and polarity loss occurs in the larval imaginal disc epithelium. However, in lgl mutant mosaic eye epithelium, ectopic Cyclin E expression and cell proliferation(More)
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