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Long-term development of psychological deficits in disability-free early multiple sclerosis (MS) was evaluated in 27 female patients over a period of 7 years and compared with healthy controls. Physical and cognitive parameters deteriorated significantly but not depression scores. In particular, the self-assessed somatic complaints remained non-similar(More)
We propose a specially optimized computer program for the user-independent calculation of the correlation dimension D and the largest Lyapunov exponent L of heart rate dynamics on the basis of only 1024 electrocardiographically recorded RR intervals (heartbeat intervals). The validity of our program was established by analyzing a set of artificial standard(More)
Cognitive and emotional capabilities were evaluated in 73 female patients with stable relapsing-remitting definite, and/or laboratory-supported multiple sclerosis (MS) and were compared with 32 matched healthy controls. Patients were categorized according to their score in the expanded disability status scale (EDSS) to either no (EDSS 0, n = 33) or few(More)
The intra- and inter-scanner variability of an automated method for MRI-based volumetry was investigated. Using SPM5 algorithms and predefined masks derived from a probabilistic whole-brain atlas, this method allows to determine the volumes of various brain structures (e.g., hemispheres, lobes, cerebellum, basal ganglia, grey and white matter etc.) in(More)
The intraoperative blood loss of 40 uncomplicated primary total hip arthroplasties was studied in a retrospective, matched pair analysis. Half of them were implanted in the supine position after complete excision of the capsule and the other half in the lateral position with preservation of the capsule. The patients were matched for mono- or bilateral(More)
In a study of central autonomic organization in interictal states of idiopathic generalized epilepsy, we measured the spontaneous oscillations of the heart rate in 8 young epileptics with normal interictal electroencaphalograms (EEGs), 6 young epileptics with epileptiform discharges in the interictal EEGs and 8 healthy controls. The temporal structure of(More)
We studied the relation between central-autonomic adaptability (largest Lyapunov exponent of heart rate dynamics) and visual learning capability (total net score in Kimura's Recurring-Figures-Test) in 15 healthy subjects and 35 patients with cerebral white matter diseases (12 with optic neuritis and 23 with multiple sclerosis), aged between 18 and 39 years.(More)
In a study of central autonomic dynamics in early multiple sclerosis, we measured the temporal oscillations of the momentary heart rate (heart rate dynamics). 11 young patients suffering from relapsing remitting definite multiple sclerosis in relapse-free and early stages of illness and 11 healthy controls were examined under vagotonic and sympathicotonic(More)
Gegenwärtige Studien konnten sowohl lineare als auch nicht-lineare Dynamik in der Variabilität der Herzfrequenz nachweisen. Der physiologische Ursprung hierfür ist bislang unbekannt. Die vorliegende Studie untersuchte den Einfluss der zerebralen Funktion auf die lineare und nicht-lineare Dynamik der Herzfrequenzvariabilität. Elektrokardiogramme von sieben(More)
In a study of central autonomic organization in early stages of experimental meningitis in rabbits, the temporal oscillations of the momentary heart rate (heart rate dynamics) were measured. In 10 anesthetized rabbits an experimental meningitis was induced by intracisternal injection of complement-C5a-fragment in a carrier solution of sodium chloride and(More)