Reiner Salzmann

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Pharmacological properties characterizing N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride (BS 100-141) as a centrally acting antihypertensive agent are described. Its action resembles that of clonidine in many respects but with important differences which are discussed. In DOCA-NaCl--hypertensive conscious rats, BS 100-141 lowers systemic blood(More)
PURPOSE The combination of interferon alfa-2a (IFN alpha) and high-dose interleukin-2 (IL-2) is active in metastatic melanoma. The addition of cisplatin (CDDP) has resulted in response rates greater than 50%. This study was performed to determine whether the addition of CDDP to a cytokine treatment regimen with IFN alpha and high-dose IL-2 influences(More)
Microsphere trapping was determined in isolated perfused Langendorff hearts of cats and rabbits with 7.9-, 8.6-and 14.6-micrometers microspheres. Only the largest spheres were completely trapped whereas significant and relevant fractions of the smaller spheres were found in the perfusate leaving the heart. These fractions were 8.3 and 3.0% of the total(More)
The in vitro cardiac effects of DPI 201-106, a novel piperazinyl-indole, were investigated. DPI 201-106 produced concentration-dependent positive inotropic effects in guinea-pig and rat left atria, kitten, rabbit and guinea-pig papillary muscles and Langendorff perfused hearts of rabbits between 10(-7) and 3 X 10(-6) mol/l. During isometric twitches,(More)
Mental and psychomotor abilities are impaired to varying degrees after general anaesthesia. This has important implications for the time over which patients are monitored in the recovery room and for the discharge of outpatients after day surgery. The present study was undertaken to compare recovery and mental and psychomotor skills in the first 60 min(More)
The interaction of the cardiotonic agent DPI 201-106 (4-[3-(4-diphenylmethyl-1-piperazinyl(-2-hydroxypropoxy]-1H-indole -2- carbonitrile) with cardiac glycosides was investigated. In rabbit papillary muscles, all effects were normalized by using potentiating paired stimulation (PPS) as the 100% reference standard. Ouabain 1 microM alone increased the force(More)
We investigate the intersection pattern of Ree-Tits unitals in the split Cayley Hexagon H(q) associated to Dickson's group G 2 (q). Using these patterns, we are able to define an incidence geometry which turns out to be a twisted field plane of order 3 2h+1 , non-desarguesian if h 6 = 0. We also show that a general point of the underlying generalized(More)