Reiner Kaschel

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Three studies investigated the relevance of affect regulation, stressful life events, and congruence between explicit achievement orientation and implicit achievement motive for subjective well-being and symptom formation. According to personality systems interactions (PSI) theory, stressful life events were expected to reduce motive congruence when the(More)
Extracts of Ginkgo biloba are widely used for the treatment of cognitive impairment. Whereas reviews have focused on the question whether ginkgo is effective to enhance cognition in general, little is known about specificity of improvement. This might be crucial for future trials, thus enabling hypotheses about sensitive outcome measures. Therefore, this(More)
Alzheimer's disease (AD) leads to a degeneration of the nucleus basalis of Meynert and thus to decreased cholinergic tonus in the brain. The transcription of endothelial nitric oxide synthase depends on an adequate cholinergic innervation of microvessels and vasoregulative abnormalities have been reported in AD. We investigated activationflow coupling to(More)
INTRODUCTION Recent reviews showed that Ginkgo biloba extract EGb 761(1) is effective to enhance performance in patients with cognitive impairment (e.g., dementia). The aim of this study was to investigate the effects of EGb 761 on memory and the specificity of such effects on distinct memory functions in middle-aged healthy volunteers. METHODS A total of(More)
Although several studies have shown that dual-tasking ability is impaired in Alzheimer's disease (AD), the stage at which this deficit manifests remains unclear. This study investigated if a new paper-and-pencil assessment of dual-tasking ability could distinguish between AD, mild cognitive impairment (MCI) and normal ageing in a sample of 50 people with(More)
Objective: To assess effects of EGb 761 on cognition and quality of life in subjects with very mild cognitive impairment. Methods: We randomized 300 subjects aged 45 to 65 with cognitive complaints and low functioning (more than one standard deviation below appropriate norm) in at least one cognitive test to double-blind treatment with once daily 240 mg EGb(More)
Durch die Alterung der Gesellschaft und einen möglichen Anstieg der Lebensarbeitszeit kommt dem kognitiven Leistungsvermögen Älterer große Bedeutung zu. Dass viele Arbeitnehmer nicht bis ins höhere Alter leistungsfähig sind, zeigt sich am rapiden Anstieg der vorzeitigen Berentung von Personen mit psychischen Erkrankungen. Die Abnahme der geistigen(More)
Due to aging of the population and a possible rise in retirement age, the cognitive capacity of older people is gaining great importance. As evidenced by the increase in early retirement due to psychosomatic disease, many employees are not capable of working at a higher age. Decreasing cognitive abilities have usually been studied in subjects over 65 years(More)
Several studies have found dual tasking to be impaired in Alzheimer's disease (AD), but unaffected by healthy ageing. It is not known if this deficit is specific to AD, or also present in other neurodegenerative disorders that can occur in later life, such as Parkinson's disease (PD). Therefore, this study investigated dual tasking in 13 people with PD, 26(More)