Reijo Sirén

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BACKGROUND Liver fat and visceral adiposity are involved in the development of the metabolic syndrome (MetS). Ectopic fat accumulation within and around the heart has been related to increased risk of heart disease. The aim of this study was to explore components of cardiac steatosis and their relationship to intra-abdominal ectopic fat deposits and(More)
BACKGROUND Ectopic accumulation of fat accompanies visceral obesity with detrimental effects. Lipid oversupply to cardiomyocytes leads to cardiac steatosis, and in animal studies lipotoxicity has been associated with impaired left ventricular (LV) function. In humans, studies have yielded inconclusive results. The aim of the study was to evaluate the role(More)
BACKGROUND Nonalcoholic fatty liver disease has emerged as a novel cardiovascular risk factor. The aim of the study was to assess the effect of different ectopic fat depots on left ventricular (LV) function in subjects with nonalcoholic fatty liver disease. METHODS AND RESULTS Myocardial and hepatic triglyceride contents were measured with 1.5 T magnetic(More)
BACKGROUND Abdominal obesity is a more important risk factor than overall obesity in predicting the development of type 2 diabetes and cardiovascular disease. From a preventive and public health point of view it is crucial that risk factors are identified at an early stage, in order to change and modify behaviour and lifestyle in high risk individuals. (More)
BACKGROUND The inverse association between socioeconomic status and cardiovascular disease is well documented. We examined whether the impact of health counselling on cardiovascular risk factors in middle-aged men differed according to socioeconomic status. METHODS We used data from a community based study assessing the risk for cardiovascular disease(More)
OBJECTIVE Ectopic fat accumulation within and around the heart has been related to increased risk of heart disease. Limited data exist on cardiac adiposity in subjects with dilated cardiomyopathy (DCM). The aim of the study was to examine the components of cardiac steatosis and their relationship to LV structure and function in non-diabetic DCM patients. (More)
The efficacy of fenoterol powder (Berotec, Boehringer-Ingelheim) was investigated in ten patients with moderate or severe asthma. Double-blind comparison to placebo powder showed a significant difference (p less than 0.05) between 30 to 180 min after a single dose of 0.2 mg. There was no difference between fenoterol powder and aerosol (0.2 mg). No adverse(More)
BACKGROUND AND AIM Cardiac steatosis has been related to increased risk of heart disease. We investigated the association between cardiac steatosis, electrocardiographic (ECG) abnormalities, and individual components of the metabolic syndrome (MetS). METHODS AND RESULTS A 12-lead ECG and laboratory data were examined in 31 men with the MetS and in 38 men(More)
BACKGROUND AND AIMS Lipid oversupply to cardiomyocytes or decreased utilization of lipids leads to cardiac steatosis. We aimed to examine the role of different circulating metabolic biomarkers as predictors of myocardial triglyceride (TG) content in non-diabetic men. METHODS AND RESULTS Myocardial and hepatic TG contents were measured with 1.5 T magnetic(More)
OBJECTIVE To examine the long-term impact of health counselling among middle-aged men at high risk of CVD. DESIGN An observational study with a 5-year follow-up. SETTING AND INTERVENTION All men aged 40 years in Helsinki have been invited to a visit to evaluate CVD risk from 2006 onwards. A modified version of the North Karelia project risk tool (CVD(More)