Regina Ofan

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BACKGROUND The expression of the regulatory cytokines interleukin (IL)-12 and IL-18 in patients with both Th1- and Th2-mediated diseases, type 1 diabetes mellitus (T1DM) and asthma, is unknown. OBJECTIVE To investigate the in vivo and in vitro IL-12 and IL-18 secretion patterns in patients with both T1DM and asthma. METHODS Peripheral blood mononuclear(More)
OBJECTIVE To compare by age and glycemic control continuous subcutaneous insulin infusion with multiple daily injections in youth with type 1 diabetes. METHODS The files of 279 patients who had type 1 diabetes and switched from multiple daily injections to continuous subcutaneous insulin infusion between 1998 and 2003 were reviewed for glycemic control,(More)
BACKGROUND Type 1 diabetes mellitus (T1DM) is a T-cell-mediated autoimmune disease that leads to the destruction of insulin-producing beta cells. Treatment with DiaPep277, a peptide derived from heat-shock protein 60 (hsp60), has been found to slow the deterioration of beta-cell function after clinical onset of diabetes in NOD mice and human adults. Our aim(More)
BACKGROUND AND OBJECTIVE T1DM and asthma are mediated by opposite arms of the cellular immune system namely T helper (Th)1 and Th2 CD4(+) cells, respectively. Our aim was to characterize the Th1/Th2 cytokine balance in patients with both T1DM and asthma. METHODS Forty-four patients, mean age 19 years were matched by gender and age, to 4 paired groups:(More)
The purpose of this study was to evaluate the psychological impact of autoantibody screening and its results on at-risk individuals and family members. Individuals who were antibody positive (AP) were identified through a large-scale screening program conducted at our institute. The sample consisted of nine families in whom 10 AP youngsters (7 M, 3 F) were(More)
Corresponding Author: Alan B. Schorr, D.O., 380 Middletown Boulevard, Suite 710, Langhorne, PA 19047; email address The combination of insulin and an amylin mimetic is an option for diabetes treatment.1,2 The effectiveness of this modality has been established, but there is a limited amount of literature regarding the use of this(More)
The actual and possible applications of computers in diabetes management are manifold. There are programs for medical information, storage and analysis, pertinent literature search, artificial intelligence, algorithms assisting the patient to adjust the insulin dose and education programs. One very useful microcomputer program DIACON is described in detail.(More)
The use of a user-friendly microcomputer system "DIACON" which stores, analyses and displays blood glucose, details of the nutrition intake, insulin dose and other details relevant to diabetes management is described. This system tested for over four years in more than 100 diabetic patients has proven to be a useful educational and therapeutic tool.
Islet cell antibodies (ICA) continue to serve as the basis of the principal serological test for definition of active autoimmunity of beta-cells. Its disadvantages are the need for human pancreatic tissue and difficulty in obtaining quantitative results. In the past decade biochemically-defined beta-cell antigens were described, leading to the development(More)