Regina C Miller

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Chronic immune activation is a major cause for progressive immunodeficiency in human immunodeficiency virus type-1 (HIV) infection. The underlying trigger, however, remains largely unknown. HIV single-stranded RNA is a potent immune activator by triggering Toll-like receptor (TLR) 7/8. Thus, we hypothesized that sustained TLR7 triggering induces chronic(More)
OBJECTIVES The outcome of Pneumocystis carinii pneumonia (PCP) in HIV-infected infants is poor, and the role of cytomegalovirus (CMV) co-infection in the course and outcome of PCP is unclear. This study describes the prevalence, clinical characteristics, management and changes in survival over time of vertically HIV-infected infants developing PCP and/or(More)
BACKGROUND Roughly one in ten persons in the industrialized world suffers from hip osteoarthritis, a disease for which there is no cure. The goal of conservative therapy is to relieve symptoms, preferably with methods that let patients assume responsibility for their own treatment, e.g., physical training. METHOD In a randomized controlled trial, we(More)
HIV infection is characterized by sustained immune activation, which is reflected by activated T cells and, in particular, by increased levels of phosphorylated STAT proteins. Here, we hypothesized that T-cell activation in HIV infection is partially due to the inability of SOCS-1 and SOCS-3 to control the JAK/STAT pathway. We found higher levels of(More)
Previous investigations have found that increasing circulating glucose availability can increase memory performance in rodents, healthy humans, and individuals with dementia of the Alzheimer's type. In this study, patients with schizophrenia, healthy control subjects, and controls with bipolar affective disorder were tested using double-blind treatment with(More)
The feasibility and efficacy of an additional progressive home-based strengthening exercise program (PHSEP) on subjects that already attended supervised institutional exercise therapy was investigated. Thirty-six hip patients with hip osteoarthritis (OA) and/or total hip replacement in at least one hip joint were randomly assigned to an intervention group(More)
BACKGROUND Excessive daytime sleepiness is a common symptom of myotonic dystrophy. Psychostimulants are drugs increasingly used to treat hypersomnia in myotonic dystrophy. OBJECTIVES To search systematically for, and combine all evidence from, randomised trials relating to the effects of psychostimulants in myotonic dystrophy patients with hypersomnia. (More)
BACKGROUND Physical disability (PD) is common among patients with osteoarthritis (OA) of the hip. Exercise therapy is proposed to be a potential intervention to reduce PD. However, the optimal targets of an exercise program are not known. PURPOSE The aim of the present study was to identify factors that explain the level of self-reported PD in patients(More)