Gene targeting of transcription factor PU.1 results in an early block to fetal hematopoiesis, with no detectable lymphoid or myeloid cells produced in mouse embryos. Furthermore, PU.1(-/-) embryonic stem (ES) cells fail to differentiate into Mac-1(+) and F4/80(+) macrophages in vitro. We have previously shown that a PU.1 transgene under the control of its… (More)
Timing of surgery for breast cancer in relation to the menstrual cycle and survival of premenopausal women. Timing of surgery in relation to the menstrual cycle in premenopausal women with operable breast cancer.